Document Detail

Rapid synthesis and secretion of intestinal apolipoprotein A-IV after gastric fat loading in rats.
MedLine Citation:
PMID:  9140017     Owner:  NLM     Status:  MEDLINE    
To further investigate the possible role of apolipoprotein A-IV (apo A-IV) in the short-term control of food intake, we examined the kinetics of intestinal apo A-IV synthesis and release into lymph and plasma after intragastric delivery of physiological amounts of lipid. Within 30 min of intragastric administration of 0.1 g of triglyceride, plasma and lymph levels of apo A-IV were similar to those produced by exogenous apo A-IV that inhibit food intake. Within 15 min, 5% of gastrically delivered radioactive lipid reached the distal small bowel and cecum; by 30 min radioactivity was evenly distributed throughout the small intestine, with 10-15% of the load in the distal gut. By 30 min, synthesis of apo A-IV was significantly stimulated in proximal and distal jejunum and distal ileum and remained elevated up to 4 h after the delivery of lipid. Our results indicate that the delivery of physiological amounts of lipid into the stomach produces a significant and rapid stimulation of apo A-IV secretion into lymph and plasma, together with a rapid delivery of lipid and increases in mucosal synthesis of apo A-IV along the entire length of the small intestine. The results support a possible role for apo A-IV in the short-term control of food intake and suggest a role for the entire gut in the integrative response of apo A-IV to a fat meal.
M D Rodriguez; T J Kalogeris; X L Wang; R Wolf; P Tso
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  272     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-05-28     Completed Date:  1997-05-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R1170-7     Citation Subset:  IM    
Department of Physiology and Biophysics, Louisiana State University, Medical Center, Shreveport 71130, USA.
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MeSH Terms
Apolipoproteins A / biosynthesis*,  metabolism
Dietary Fats*
Eating / physiology*
Fat Emulsions, Intravenous / administration & dosage,  metabolism
Gastric Mucosa / physiology*
Lymph / physiology
Lymphatic System / physiology*
Rats, Sprague-Dawley
Stomach / physiology*
Time Factors
Triolein / administration & dosage,  metabolism
Grant Support
Reg. No./Substance:
0/Apolipoproteins A; 0/Dietary Fats; 0/Fat Emulsions, Intravenous; 0/apolipoprotein A-IV; 122-32-7/Triolein

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