Document Detail

Rapid, stress-induced modification of the benzodiazepine receptor-coupled chloride ionophore.
MedLine Citation:
PMID:  3015336     Owner:  NLM     Status:  MEDLINE    
Rapid changes in the chloride ionophore component of the benzodiazepine-GABA receptor complex were observed in cerebral cortical membranes from rats exposed to a brief, ambient temperature swim stress. These changes were manifest as: an increase in both the efficacy and potency of chloride ions to enhance [3H]flunitrazepam binding, and an increase in both the number of [35S]t-butylbicyclophosphorothionate (a ligand that binds at or near the GABAA receptor-gated chloride ionophore) binding sites and the apparent affinity of this radioligand. These studies demonstrate that the GABA-gated, benzodiazepine-coupled chloride ionophore, which can be considered the effector component of this 'supramolecular complex', is rapidly modulated by acute stress. Such changes could represent the compensatory response of an organism to stressful or anxiety provoking changes in the environment.
H Havoundjian; S M Paul; P Skolnick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  375     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-09-16     Completed Date:  1986-09-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  401-6     Citation Subset:  IM    
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MeSH Terms
Bicyclo Compounds / metabolism
Bicyclo Compounds, Heterocyclic*
Cerebral Cortex / metabolism*
Chlorides / pharmacology*
Flunitrazepam / metabolism*
Rats, Inbred Strains
Receptors, GABA-A / metabolism*
Stimulation, Chemical
Stress, Physiological / metabolism*
Reg. No./Substance:
0/Bicyclo Compounds; 0/Bicyclo Compounds, Heterocyclic; 0/Chlorides; 0/Receptors, GABA-A; 1622-62-4/Flunitrazepam; 70636-86-1/tert-butylbicyclophosphorothionate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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