Document Detail

Rapid-sequence induction technique in patients with severe ventricular dysfunction.
MedLine Citation:
PMID:  17171949     Owner:  NLM     Status:  MEDLINE    
The hemodynamic effects of a rapid-sequence induction and intubation technique using etomidate, fentanyl, and succinylcholine for emergency surgery in patients with severe ventricular dysfunction were studied. Ten patients undergoing orthotopic heart transplantation received fentanyl, 10 microg/kg, etomidate, 0.3 mg/kg, and succinylcholine, 1.5 mg/kg, intravenously (IV) in rapid-sequence fashion for induction. Intubation was performed 60 seconds later. Heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary arterial pressure (MPAP), pulmonary arterial occlusion pressure (PAo), and cardiac index (CI) were measured preinduction, postinduction, and 1 minute after intubation. Systemic vascular resistance index (SVRI) and pulmonary vascular resistance index (PVRI) were calculated from the measured data. No statistically significant changes in hemodynamics occurred with induction or intubation. These results indicate that etomidate, fentanyl, and succinylcholine given in a rapid-sequence technique produce a hemodynamically stable induction with minimal response to intubation in patients with end-stage cardiac disease.
P M Waterman; R Bjerke
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiothoracic anesthesia     Volume:  2     ISSN:  0888-6296     ISO Abbreviation:  J Cardiothorac Anesth     Publication Date:  1988 Oct 
Date Detail:
Created Date:  2006-12-18     Completed Date:  2007-01-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8709732     Medline TA:  J Cardiothorac Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  602-6     Citation Subset:  IM    
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, PA 15213-2582, USA.
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MeSH Terms
Anesthesia / methods*
Blood Pressure / drug effects
Etomidate / administration & dosage*
Fentanyl / administration & dosage*
Heart Rate / drug effects
Heart Transplantation
Intubation, Intratracheal
Middle Aged
Succinylcholine / administration & dosage*
Ventricular Dysfunction / physiopathology,  surgery*
Reg. No./Substance:
306-40-1/Succinylcholine; 33125-97-2/Etomidate; 437-38-7/Fentanyl

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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