Document Detail

Rapid reversal of critical haemodynamic compromise with nitric oxide in a parturient with amniotic fluid embolism.
MedLine Citation:
PMID:  17337177     Owner:  NLM     Status:  MEDLINE    
We describe a case of amniotic fluid embolism presenting as cardiovascular collapse during labour. After initial resuscitation and emergency caesarean section, the patient was transferred to the intensive care unit with profound hypoxaemia, a high inotropic drug requirement and severe coagulopathy. A transoesophageal echocardiogram demonstrated acute right ventricular overload, severe pulmonary artery hypertension and marked diastolic dysfunction of the left ventricle secondary to a dilated right ventricle. The introduction of nitric oxide at 40 ppm produced a dramatic improvement in her cardiorespiratory status. Mother and baby both survived with no apparent long term sequelae.
N J McDonnell; B O Chan; R W Frengley
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-03-06
Journal Detail:
Title:  International journal of obstetric anesthesia     Volume:  16     ISSN:  0959-289X     ISO Abbreviation:  Int J Obstet Anesth     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-12     Completed Date:  2007-08-28     Revised Date:  2008-05-30    
Medline Journal Info:
Nlm Unique ID:  9200430     Medline TA:  Int J Obstet Anesth     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  269-73     Citation Subset:  IM    
Department of Anaesthesia, Waikato Hospital, Hamilton, New Zealand.
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MeSH Terms
Analgesia, Epidural
Anesthesia, General
Apgar Score
Blood Coagulation Tests
Echocardiography, Transesophageal
Embolism, Amniotic Fluid / physiopathology*
Hypertension, Pulmonary / drug therapy,  etiology
Infant, Newborn
Nitric Oxide / therapeutic use*
Shock / drug therapy*,  etiology*
Reg. No./Substance:
10102-43-9/Nitric Oxide
Comment In:
Int J Obstet Anesth. 2008 Apr;17(2):189-90; author reply 190   [PMID:  18308557 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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