Document Detail


Rapid response of marginal zone B cells to viral particles.
MedLine Citation:
PMID:  15383559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Marginal zone (MZ) B cells are thought to be responsible for the first wave of Abs against bacterial Ags. In this study, we assessed the in vivo response of MZ B cells in mice immunized with viral particles derived from the RNA phage Qbeta. We found that both follicular (FO) and MZ B cells responded to immunization with viral particles. MZ B cells responded with slightly faster kinetics, but numerically, FO B cells dominated the response. B1 B cells responded similarly to MZ B cells. Both MZ and FO B cells underwent isotype switching, with MZ B cells again exhibiting faster kinetics. In fact, almost all Qbeta-specific MZ B cells expressed surface IgG by day 5. Histological analysis demonstrated that a population of activated B cells remain associated with the MZ, probably due to the elevated integrin levels expressed by these cells. Thus, both MZ and FO B cells respond with rapid proliferation to viral infection and both populations undergo isotype switching, but MZ B cells remain in the MZ and may be responsible for local Ab production, opsonizing pathogens entering the spleen.
Authors:
Dominique Gatto; Christiane Ruedl; Bernhard Odermatt; Martin F Bachmann
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  173     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-22     Completed Date:  2004-11-15     Revised Date:  2006-03-10    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4308-16     Citation Subset:  AIM; IM    
Affiliation:
Cytos Biotechnology AG, Zurich-Schlieren, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Allolevivirus / immunology*,  metabolism
Animals
Antigens, CD / biosynthesis
B-Lymphocyte Subsets / cytology,  immunology*,  metabolism,  virology*
Biological Markers / analysis
Female
Flow Cytometry
Germinal Center / cytology,  immunology,  metabolism,  virology
Immunoglobulin Class Switching
Immunoglobulin G / biosynthesis
Immunoglobulin M / biosynthesis
Integrin alpha4beta1 / biosynthesis
Lymphocyte Cooperation / immunology
Lymphocyte Function-Associated Antigen-1 / biosynthesis
Membrane Glycoproteins / biosynthesis
Mice
Mice, Inbred C57BL
Mice, Knockout
Receptors, Virus / metabolism
Spleen / cytology,  immunology*,  metabolism,  virology*
T-Lymphocytes, Helper-Inducer / immunology,  virology
Time Factors
Up-Regulation / immunology
Virion / immunology*,  metabolism
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/Biological Markers; 0/CD9 antigen; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Integrin alpha4beta1; 0/Lymphocyte Function-Associated Antigen-1; 0/Membrane Glycoproteins; 0/Receptors, Virus

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