Document Detail


Rapid remodeling of airway vascular architecture at birth.
MedLine Citation:
PMID:  20730909     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent advances have documented the development of lung vasculature before and after birth, but less is known of the growth and maturation of airway vasculature. We sought to determine whether airway vasculature changes during the perinatal period and when the typical adult pattern develops. On embryonic day 16.5 mouse tracheas had a primitive vascular plexus unlike the adult airway vasculature, but instead resembling the yolk sac vasculature. Soon after birth (P0), the primitive vascular plexus underwent abrupt and extensive remodeling. Blood vessels overlying tracheal cartilage rings regressed from P1 to P3 but regrew from P4 to P7 to form the hierarchical, segmented, ladder-like adult pattern. Hypoxia and HIF-1α were present in tracheal epithelium over vessels that survived but not where they regressed. These findings reveal the plasticity of airway vasculature after birth and show that these vessels can be used to elucidate factors that promote postnatal vascular remodeling and maturation.
Authors:
Amy Ni; Erin Lashnits; Li-Chin Yao; Peter Baluk; Donald M McDonald
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  239     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-14     Completed Date:  2011-01-31     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2354-66     Citation Subset:  IM    
Copyright Information:
Developmental Dynamics 239:2354-2366, 2010. © 2010 Wiley-Liss, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Anoxia / metabolism
Apoptosis / physiology
Blood Vessels* / anatomy & histology,  embryology,  growth & development
Cell Proliferation
Endothelial Cells / cytology,  physiology
Female
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Lung* / blood supply,  embryology,  growth & development
Mice
Mice, Inbred C57BL
Neovascularization, Physiologic / physiology*
Pregnancy
Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors
Grant Support
ID/Acronym/Agency:
CA82923/CA/NCI NIH HHS; HL24136/HL/NHLBI NIH HHS; HL59157/HL/NHLBI NIH HHS; HL96511/HL/NHLBI NIH HHS; P01 HL024136/HL/NHLBI NIH HHS; P01 HL024136-30/HL/NHLBI NIH HHS; P01 HL024136-31A1/HL/NHLBI NIH HHS; P01 HL024136-31A18647/HL/NHLBI NIH HHS; R01 HL059157/HL/NHLBI NIH HHS; R01 HL059157-13/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Hypoxia-Inducible Factor 1, alpha Subunit; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2
Comments/Corrections

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