| Rapid remodeling of airway vascular architecture at birth. | |
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MedLine Citation:
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PMID: 20730909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent advances have documented the development of lung vasculature before and after birth, but less is known of the growth and maturation of airway vasculature. We sought to determine whether airway vasculature changes during the perinatal period and when the typical adult pattern develops. On embryonic day 16.5 mouse tracheas had a primitive vascular plexus unlike the adult airway vasculature, but instead resembling the yolk sac vasculature. Soon after birth (P0), the primitive vascular plexus underwent abrupt and extensive remodeling. Blood vessels overlying tracheal cartilage rings regressed from P1 to P3 but regrew from P4 to P7 to form the hierarchical, segmented, ladder-like adult pattern. Hypoxia and HIF-1α were present in tracheal epithelium over vessels that survived but not where they regressed. These findings reveal the plasticity of airway vasculature after birth and show that these vessels can be used to elucidate factors that promote postnatal vascular remodeling and maturation. |
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Authors:
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Amy Ni; Erin Lashnits; Li-Chin Yao; Peter Baluk; Donald M McDonald |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental dynamics : an official publication of the American Association of Anatomists Volume: 239 ISSN: 1097-0177 ISO Abbreviation: Dev. Dyn. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-14 Completed Date: 2011-01-31 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9201927 Medline TA: Dev Dyn Country: United States |
Other Details:
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Languages: eng Pagination: 2354-66 Citation Subset: IM |
Copyright Information:
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Developmental Dynamics 239:2354-2366, 2010. © 2010 Wiley-Liss, Inc. |
Affiliation:
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Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Anoxia / metabolism Apoptosis / physiology Blood Vessels* / anatomy & histology, embryology, growth & development Cell Proliferation Endothelial Cells / cytology, physiology Female Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Lung* / blood supply, embryology, growth & development Mice Mice, Inbred C57BL Neovascularization, Physiologic / physiology* Pregnancy Vascular Endothelial Growth Factor Receptor-2 / antagonists & inhibitors |
| Grant Support | |
ID/Acronym/Agency:
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CA82923/CA/NCI NIH HHS; HL24136/HL/NHLBI NIH HHS; HL59157/HL/NHLBI NIH HHS; HL96511/HL/NHLBI NIH HHS; P01 HL024136-30/HL/NHLBI NIH HHS; P01 HL024136-31A1/HL/NHLBI NIH HHS; P01 HL024136-31A18647/HL/NHLBI NIH HHS; R01 HL059157/HL/NHLBI NIH HHS; R01 HL059157-13/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Hypoxia-Inducible Factor 1, alpha Subunit; EC 2.7.10.1/Vascular Endothelial Growth Factor Receptor-2 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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