| Rapid reduction of liver steatosis in omega3-depleted rats injected with a novel lipid emulsion. | |
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MedLine Citation:
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PMID: 18726832 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The bolus intravenous administration of a novel medium-chain triglyceride: fish oil emulsion (MCT:FO) to normal subjects was recently found to increase within 60 min the amount of long-chain polyunsaturated omega3 fatty acids ( omega3) in platelet and leukocyte phospholipids and, hence, was proposed as a tool to prevent such pathological events as cardiac arrhythmia in selected patients who have to undergo urgent anesthesia and/or surgery. This study investigates whether other cells located outside the vascular bed may also benefit from this procedure for replenishing phospholipids with omega3. For such a purpose, the MCT:FO emulsion (1.0 ml) was injected into normal or omega3-depleted rats examined, one hour later, for the content and fatty acid pattern of liver triglycerides and phospholipids. Control experiments included the administration of saline or a medium-chain triglyceride:olive oil emulsion. The results reveal that the bolus intravenous injection of MCT:FO to the omega3-depleted rats resulted in the enrichment of liver phospholipids in omega3 and a marked reduction in hepatic steatosis. In conclusion, it is proposed that such a procedure may indeed allow a rapid supply of omega3 not only to circulating and vascular endothelial cells but also to extravascular cells, with a resulting correction of the biochemical and biophysical defects linked to a deficiency in these fatty acids. |
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Authors:
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Y A Carpentier; S Peltier; L Portois; J-L Sebedio; X Leverve; W J Malaisse |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-22 |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 40 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-14 Completed Date: 2009-03-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 875-9 Citation Subset: IM |
Affiliation:
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L. Deloyers Laboratory for Experimental Surgery, Brussels Free University, Brussels, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Fat Emulsions, Intravenous / pharmacology* Fatty Acids / metabolism Fatty Acids, Omega-3 / metabolism* Fatty Liver / drug therapy*, metabolism Fish Oils / administration & dosage, pharmacology Liver / drug effects, metabolism Male Phospholipids / metabolism Plant Oils / administration & dosage, pharmacology Rats Triglycerides / administration & dosage, metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Fat Emulsions, Intravenous; 0/Fatty Acids; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Phospholipids; 0/Plant Oils; 0/Triglycerides; 8001-25-0/olive oil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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