Document Detail


Rapid quantification of oxygen tension in blood flow with a fluorine nanoparticle reporter and a novel blood flow-enhanced-saturation-recovery sequence.
MedLine Citation:
PMID:  22915328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a novel blood flow-enhanced-saturation-recovery (BESR) sequence, which allows rapid in vivo T1 measurement of blood for both (1)H and (19)F nuclei. BESR sequence is achieved by combining homogeneous spin preparation and time-of-flight image acquisition and therefore preserves high time efficiency and signal-to-noise ratio for (19)F imaging of circulating perfluorocarbon nanoparticles comprising a perfluoro-15-crown-5-ether core and a lipid monolayer (nominal size = 250 nm). The consistency and accuracy of the BESR sequence for measuring T1 of blood was validated experimentally. With a confirmed linear response feature of (19)F R1 with oxygen tension in both salt solution and blood sample, we demonstrated the feasibility of the BESR sequence to quantitatively determine the oxygen tension within mouse left and right ventricles under both normoxia and hyperoxia conditions. Thus, (19)F BESR MRI of circulating perfluorocarbon nanoparticles represents a new approach to noninvasively evaluate intravascular oxygen tension.
Authors:
Lingzhi Hu; Junjie Chen; Xiaoxia Yang; Shelton D Caruthers; Gregory M Lanza; Samuel A Wickline
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-22
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  70     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-24     Completed Date:  2014-01-30     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  176-83     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Flow Velocity / physiology
Coronary Circulation / physiology*
Crown Ethers / diagnostic use*
Heart Ventricles / metabolism*
Magnetic Resonance Spectroscopy / methods*
Mice
Nanocapsules / diagnostic use*
Oximetry / methods*
Oxygen / blood*
Grant Support
ID/Acronym/Agency:
R01 AR056223/AR/NIAMS NIH HHS; R01 CA154737/CA/NCI NIH HHS; R01 HL073646/HL/NHLBI NIH HHS; R01 HL073646/HL/NHLBI NIH HHS; R01 HL113392/HL/NHLBI NIH HHS; R21 DK095555/DK/NIDDK NIH HHS; U01 NS073457/NS/NINDS NIH HHS; U54 CA119342/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Crown Ethers; 0/Nanocapsules; 0/perfluoro-15-crown-5-ether; S88TT14065/Oxygen
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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