Document Detail


Rapid quantification of oxygen tension in blood flow with a fluorine nanoparticle reporter and a novel blood flow-enhanced-saturation-recovery sequence.
MedLine Citation:
PMID:  22915328     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We present a novel blood flow-enhanced-saturation-recovery (BESR) sequence, which allows rapid in vivo T(1) measurement of blood for both (1) H and (19) F nuclei. BESR sequence is achieved by combining homogeneous spin preparation and time-of-flight image acquisition and therefore preserves high time efficiency and signal-to-noise ratio for (19) F imaging of circulating perfluorocarbon nanoparticles comprising a perfluoro-15-crown-5-ether core and a lipid monolayer (nominal size = 250 nm). The consistency and accuracy of the BESR sequence for measuring T(1) of blood was validated experimentally. With a confirmed linear response feature of (19) F R(1) with oxygen tension in both salt solution and blood sample, we demonstrated the feasibility of the BESR sequence to quantitatively determine the oxygen tension within mouse left and right ventricles under both normoxia and hyperoxia conditions. Thus, (19) F BESR MRI of circulating perfluorocarbon nanoparticles represents a new approach to noninvasively evaluate intravascular oxygen tension. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.
Authors:
Lingzhi Hu; Junjie Chen; Xiaoxia Yang; Shelton D Caruthers; Gregory M Lanza; Samuel A Wickline
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-22
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  -     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Department of Physics, Washington University, St. Louis, Missouri, USA.
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