Document Detail

Rapid progression of amyotrophic lateral sclerosis presenting during pregnancy: a case report.
MedLine Citation:
PMID:  15937610     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurologic disease that is rare within the obstetric population. Only 5 reports of ALS in pregnancy have appeared in the medical literature since 1977. CASE: A previously healthy 25-year-old pregnant woman with 2 previous births presented with generalized weakness at 22 weeks' gestation. Initial laboratory values were all normal. She was admitted to hospital at 29 weeks' gestation and intubated because of respiratory compromise. Daily biophysical profiles and amniotic fluid indices were normal. Labour was induced at 34.5 weeks' gestation, and delivery was uncomplicated. She died at 9 months postpartum. CONCLUSION: Pregnancy complicated by the onset of ALS is a rare event. Complications of this disease mainly affect the respiratory system. Death in this case occurred more rapidly than in other previously reported cases.
David E Leveck; Gregory A Davies
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstétrique et gynécologie du Canada : JOGC     Volume:  27     ISSN:  1701-2163     ISO Abbreviation:  J Obstet Gynaecol Can     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-06-06     Completed Date:  2005-09-13     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101126664     Medline TA:  J Obstet Gynaecol Can     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  360-2     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Queen's University, Kingston ON.
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MeSH Terms
Amyotrophic Lateral Sclerosis / complications*
Fatal Outcome
Gestational Age
Pregnancy Complications*
Pregnancy Outcome
Respiratory Insufficiency / etiology

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