| Rapid onset frontal leukodystrophy with decreased diffusion coefficient and neuroaxonal spheroids. | |
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MedLine Citation:
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PMID: 19458985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adult leukodystrophies with neuroaxonal spheroids (LNS) constitute a heterogeneous group of genetic diseases. Herein, we report on two unrelated patients with LNS characterized by rapid onset, predominant involvement of the frontal white matter, and areas of decreased apparent diffusion coefficient on diffusion-weighted imaging. We found similar cases in the literature and propose that they represent a distinct entity within the group of LNS. Further studies will be required to identify its molecular basis. |
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Authors:
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Elisabeth Maillart; Audrey Rousseau; Damien Galanaud; Fran??oise Gray; Marc Polivka; Pierre Labauge; Jean-Jacques Hauw; Olivier Lyon-Caen; Olivier Gout; Fr??d??ric Sedel |
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Publication Detail:
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Type: Case Reports; Journal Article; Review Date: 2009-05-21 |
Journal Detail:
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Title: Journal of neurology Volume: 256 ISSN: 1432-1459 ISO Abbreviation: J. Neurol. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-01 Completed Date: 2010-01-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0423161 Medline TA: J Neurol Country: Germany |
Other Details:
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Languages: eng Pagination: 1649-54 Citation Subset: IM |
Affiliation:
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Federation of Nervous System Diseases, H??pital de la Salp??tri??re, Assistance Publique-H??pitaux de Paris, Universit?? Pierre et Marie Curie (Paris VI), 47 Boulevard de l'H??pital, 75651 Paris Cedex 13, France. elisabethmaillart@yahoo.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Diseases / diagnosis, pathology* Diffusion Magnetic Resonance Imaging Female Frontal Lobe / pathology* Humans Nerve Fibers, Myelinated / pathology Time Factors |
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