Document Detail

Rapid noninvasive continuous monitoring of oxygenation in cerebral ischemia and hypoxia.
MedLine Citation:
PMID:  21165773     Owner:  NLM     Status:  In-Process    
The brain is most sensitively dependent on oxygen to maintain its normal function. Methods to assess the degree of its oxygenation have generally been invasive and indirect. Rapid assessment of brain oxygenation is particularly vital during cerebrospinal ischemia and hypoxia. We have developed a noninvasive electro-optical method using pulsed near-infrared (NIR) light to quantify brain oxygenation during ischemia and hypoxia in anesthetized rabbits. Cerebral ischemia was induced through 30-40 s of bi-lateral carotid artery occlusion. Cerebral hypoxia was induced by varying inspired oxygen levels. The NIR light response to the interventions was expressed in terms of relative absorption (RA). Results showed that our pulsed NIR system could rapidly detect sudden alterations in oxygenation and blood flow to the brain. The response patterns during cerebral ischemia and hypoxia were significantly different, although both decreased brain oxygenation. The overall RA response to ischemia was much faster (in seconds) than during hypoxia (in minutes). These different response patterns can serve as early warning signal of low brain oxygenation and to discriminate the cause of the diminished oxygenation. The present pulsed NIR system is capable to provide a rapid, noninvasive and continuous monitoring of such decreases in brain oxygenation.
John K-J Li; Tijun Wang; Hongjun Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular engineering (Dordrecht, Netherlands)     Volume:  10     ISSN:  1573-6806     ISO Abbreviation:  Cardiovasc Eng     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101132083     Medline TA:  Cardiovasc Eng     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  IM    
Department of Biomedical Engineering, Cardiovascular Engineering Lab, 599 Taylor Rd, Piscataway, NJ 08854, USA.
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