Document Detail

Rapid nocturnal increase in ovine pineal N-acetyltransferase activity and melatonin synthesis: effects of cycloheximide.
MedLine Citation:
PMID:  2411856     Owner:  NLM     Status:  MEDLINE    
Thirty minutes after the onset of darkness, ovine pineal arylalkylamine N-acetyltransferase, N-acetylserotonin, and melatonin increase 5- to 10-fold. No significant changes in hydroxyindole-O-methyltransferase, 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, 5-hydroxytryptophol, 5-methoxyindoleacetic acid, and 5-methoxytryptophol are detected at this time. Administration of cycloheximide inhibits the rise in N-acetyltransferase and N-acetylserotonin, but not melatonin. Unexpectedly, 5-methoxytryptophol increases after cycloheximide treatment. Taken together, these results, although consistent in part with a role for serotonin N-acetylation in the regulation of melatonin synthesis in sheep, indicate that an N-acetyltransferase-independent mechanism may also be involved.
M A Namboodiri; D Sugden; D C Klein; R Grady; I N Mefford
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  45     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-09-30     Completed Date:  1985-09-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  832-5     Citation Subset:  IM    
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MeSH Terms
Acetylserotonin O-Methyltransferase / metabolism
Acetyltransferases / metabolism*
Arylamine N-Acetyltransferase / metabolism*
Cycloheximide / pharmacology*
Hydroxyindoleacetic Acid / analysis
Melatonin / analysis,  biosynthesis*,  blood
Pineal Gland / analysis,  drug effects*,  metabolism
Serotonin / analysis
Reg. No./Substance:
50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 66-81-9/Cycloheximide; 73-31-4/Melatonin; EC O-Methyltransferase; EC 2.3.1.-/Acetyltransferases; EC N-Acetyltransferase

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