| Rapid nocturnal increase in ovine pineal N-acetyltransferase activity and melatonin synthesis: effects of cycloheximide. | |
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MedLine Citation:
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PMID: 2411856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thirty minutes after the onset of darkness, ovine pineal arylalkylamine N-acetyltransferase, N-acetylserotonin, and melatonin increase 5- to 10-fold. No significant changes in hydroxyindole-O-methyltransferase, 5-hydroxytryptamine, 5-hydroxyindoleacetic acid, 5-hydroxytryptophol, 5-methoxyindoleacetic acid, and 5-methoxytryptophol are detected at this time. Administration of cycloheximide inhibits the rise in N-acetyltransferase and N-acetylserotonin, but not melatonin. Unexpectedly, 5-methoxytryptophol increases after cycloheximide treatment. Taken together, these results, although consistent in part with a role for serotonin N-acetylation in the regulation of melatonin synthesis in sheep, indicate that an N-acetyltransferase-independent mechanism may also be involved. |
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Authors:
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M A Namboodiri; D Sugden; D C Klein; R Grady; I N Mefford |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of neurochemistry Volume: 45 ISSN: 0022-3042 ISO Abbreviation: J. Neurochem. Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1985-09-30 Completed Date: 1985-09-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985190R Medline TA: J Neurochem Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 832-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylserotonin O-Methyltransferase
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metabolism Acetyltransferases / metabolism* Animals Arylamine N-Acetyltransferase / metabolism* Cricetinae Cycloheximide / pharmacology* Darkness* Haplorhini Hydroxyindoleacetic Acid / analysis Male Melatonin / analysis, biosynthesis*, blood Pineal Gland / analysis, drug effects*, metabolism Rats Serotonin / analysis Sheep |
| Chemical | |
Reg. No./Substance:
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50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid; 66-81-9/Cycloheximide; 73-31-4/Melatonin; EC 2.1.1.4/Acetylserotonin O-Methyltransferase; EC 2.3.1.-/Acetyltransferases; EC 2.3.1.5/Arylamine N-Acetyltransferase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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