Document Detail

Rapid metabolic failure in spontaneously hypertensive rats after middle cerebral artery ligation.
MedLine Citation:
PMID:  1749364     Owner:  NLM     Status:  MEDLINE    
The metabolic characteristics of the penumbral region were examined in spontaneously hypertensive rats one hour after permanent middle cerebral artery occlusion. The effect of hyperglycemia on this region was examined by providing a glucose load prior to occlusion. The depressed concentrations of adenosine triphosphate and elevated levels of lactate in the penumbral region were similar to those found in the ischemic focus. The purported neuroprotective effect of hyperglycemia in the penumbral region was not reflected in an increased high-energy phosphate level in the penumbral region. The rapid deterioration of the metabolic status of this region in this strain of rat suggests that the increased consistency of infarction may come at the expense of the penumbral region, and thus this model may not be well suited for the study of metabolic changes and perhaps even therapeutic intervention.
W R Selman; R C Crumrine; C C Rosenstein; C Jenkins; J C LaManna; R A Ratcheson; W D Lust
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Metabolic brain disease     Volume:  6     ISSN:  0885-7490     ISO Abbreviation:  Metab Brain Dis     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-01-17     Completed Date:  1992-01-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  57-64     Citation Subset:  IM    
Department of Neurological Surgery, Case Western Reserve University, School of Medicine, Cleveland, Ohio.
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MeSH Terms
Adenosine Triphosphate / metabolism
Blood Glucose / metabolism
Blood Pressure / physiology
Brain / metabolism
Carbon Dioxide / metabolism
Cerebral Arteries
Cerebral Infarction / metabolism*
Heart Rate / physiology
Hyperglycemia / metabolism
Hypertension / metabolism*
Lactates / blood
Oxygen Consumption / physiology
Rats, Inbred SHR
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Lactates; 124-38-9/Carbon Dioxide; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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