Document Detail

Rapid mechanical ventilation effects on tracheal airway pressure, lung volume, and blood gases of rabbits.
MedLine Citation:
PMID:  3530269     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to demonstrate that ventilation of rabbit lungs (whose mechanics are similar to those of human infants) at rapid rates will lead to large alterations in tracheal airway pressures, tidal volume, and functional residual capacity (FRC) with only minor changes in arterial blood gases. Thirteen rabbits were ventilated at rates of 30, 60, 90, and 120 breaths per minutes (BPM) with pressures of 17/2 cm H2O. Tracheal peak inspiratory pressure (PIP) was always lower than ventilator PIP and decreased to 11 +/- 1 cm H2O at 120 BPM. Positive end-expiratory pressure (PEEP) in the trachea was always greater than 2 cm H2O and increased with rate (3.5 cm H2O at 120 BPM). Tidal volume decreased as rates were increased such that rates above 60 BPM resulted in insignificant changes in minute ventilation and arterial blood gases. However, the FRC increased from 16 (30 BPM) to 25 ml/kg (120 BPM), a 56% increase, suggesting large increases in end-expiratory alveolar pressure. We conclude that rapid-rate ventilation (greater than 60 BPM) of healthy rabbits results in significant increases in both tracheal PEEP and FRC without significantly affecting arterial blood gases. The increased tracheal PEEP and FRC are manifestations of inadvertent PEEP. The increased FRC without concomitant increase in PaO2 implicates alveolar overdistention. We speculate that rapid-rate ventilation of human infants having lung mechanics similar to rabbits, will also result in inadvertent PEEP and alveolar overdistention.
F Gonzalez; P Richardson; J R Carlstrom; C L Bose
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  3     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1986 Oct 
Date Detail:
Created Date:  1986-10-30     Completed Date:  1986-10-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-51     Citation Subset:  IM    
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MeSH Terms
Blood Gas Analysis
Lung / physiology*
Positive-Pressure Respiration
Residual Volume
Respiration, Artificial*
Tidal Volume
Trachea / physiology*

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