| Rapid ischemic preconditioning with a short reperfusion time prevents delayed paraplegia in a rabbit model. | |
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MedLine Citation:
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PMID: 21997656 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Surgery for thoracic and thoracoabdominal aortic aneurysms can be complicated by a significant incidence of neurogenic deficits due to spinal cord ischemia. In this study, we investigated whether ischemic preconditioning (IPC) improves neurologic outcome in a rabbit model.Methods: Forty rabbits underwent infrarenal aortic occlusion. The IPC group (n = 20) had 10 minutes of aortic occlusion to induce spinal cord ischemia, 40 minutes of reperfusion, and 30 minutes of ischemia, whereas the control group (n = 20) had only 30 minutes of ischemia. Tarlov scoring (0, paraplegia; 4, normal) was used to evaluate neurologic functions 7 days later, and spinal cord segments (L4-L6) were stained with hematoxylin and eosin for histologic evaluation.Results: Complete paraplegia (grade 0) occurred in 15 (75%) of the 20 control animals, whereas in the IPC group, 13 (65%) of 20 animals were completely normal (grade 4) (P < .05).Conclusion: IPC is beneficial for protecting against neurologic damage after transient aortic occlusion in a rabbit model; however, the protective mechanisms are not clear. |
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Authors:
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Mehmet Ozkokeli; Mehmet Ugur Es; Ugur Filizcan; Murat Ugurlucan; Ahmet Sasmazel; Cenk Tataroglu |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The heart surgery forum Volume: 14 ISSN: 1522-6662 ISO Abbreviation: Heart Surg Forum Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100891112 Medline TA: Heart Surg Forum Country: United States |
Other Details:
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Languages: eng Pagination: E317-21 Citation Subset: IM |
Affiliation:
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Department of Cardiovascular Surgery, Kartal Kosuyolu Research and Training Hospital, Istanbul. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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