Document Detail

Rapid intravenous administration of amino acids prevents biliary sludge induced by total parenteral nutrition in humans.
MedLine Citation:
PMID:  11180878     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate whether daily rapid intravenous administration of amino acids (IVAA) prevented the formation of biliary sludge in humans receiving long-term total parenteral nutrition (TPN). Thirty adult patients receiving TPN for more than 28 consecutive days were studied. They were randomized to receive either saline solution (placebo) intravenously (15 patients) or 6.9% branched chain amino acid (BCAA)-enriched amino acid (15 synthetic amino acids; Freamine HBC) solution given by administration rapid intravenous (15 patients). The groups were similar with respect to age, sex, diagnosis, liver function test results, amylase levels, TPN time, and time of study. All patients underwent weekly ultrasound studies. Volume and emptying studies of the gallbladder in response to the study drug were performed after 1 week. As a result, none of the patients receiving rapid IVAA had sludge, whereas 11 of the 15 patients receiving placebo had sludge (P < 0.01). Results of emptying studies showed significant contraction of the gallbladder in those in the rapid IVAA group, but not in the placebo group. Consequently, the data suggest that rapid IVAA given daily prevents TPN-induced stasis and sludge in the gallbladder. We conclude that rapid IVAA should be used as routine prophylaxis against biliary sludge and formation of gallstones in patients receiving long-term TPN.
Z S Wu; L Yu; Y J Lin; Z J Jun; W S Min; Y Jun; Z B Hua
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hepato-biliary-pancreatic surgery     Volume:  7     ISSN:  0944-1166     ISO Abbreviation:  J Hepatobiliary Pancreat Surg     Publication Date:  2000  
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-04-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9431940     Medline TA:  J Hepatobiliary Pancreat Surg     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  504-9     Citation Subset:  IM    
Department of Surgery, the First People's Hospital of Ri Zhao City, Shandong Province, 276800, P.R. China.
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MeSH Terms
Amino Acids / administration & dosage*,  therapeutic use
Cholelithiasis / prevention & control*
Gallbladder / ultrasonography
Infusions, Intravenous
Parenteral Nutrition, Total* / adverse effects
Reg. No./Substance:
0/Amino Acids; 65072-01-7/Travasol

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