Document Detail

Rapid innate control of antigen abrogates adaptive immunity.
MedLine Citation:
PMID:  23198899     Owner:  NLM     Status:  MEDLINE    
Natural killer (NK) cells provide an immediate first line of defence against viral infections. Memory responses, maintained by CD4(+) T cells, require exposure to viral antigen and provide long-term protection against future infections. It is known that NK cells can promote the development of the adaptive response through cytokine production and cross-talk with antigen-presenting cells. In this paper however, we summarize a series of recent publications, in mouse models and for the first time in man, with the unifying message that rapid viral antigen control by the innate immune system limits antigen exposure to CD4(+) cells thereby abrogating the development of a memory response. We discuss the significant implication of these studies on viral treatment strategies and immunization models.
Thomas P I Pembroke; Awen M Gallimore; Andrew Godkin
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Immunology     Volume:  138     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-13     Completed Date:  2013-04-26     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  England    
Other Details:
Languages:  eng     Pagination:  293-7     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
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MeSH Terms
Adaptive Immunity*
Antigens, Viral / immunology*
CD4-Positive T-Lymphocytes / immunology*,  pathology,  virology
CD8-Positive T-Lymphocytes / immunology,  pathology,  virology
Cytokines / biosynthesis,  immunology
Dendritic Cells / immunology,  pathology,  virology
Immunity, Innate*
Immunologic Memory
Killer Cells, Natural / immunology*,  pathology,  virology
Models, Immunological
Virus Diseases / immunology*,  pathology,  virology
Viruses / immunology
Reg. No./Substance:
0/Antigens, Viral; 0/Cytokines

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