| Rapid injection of rocuronium reduces withdrawal movement on injection. | |
| | |
MedLine Citation:
|
PMID: 19833276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
STUDY OBJECTIVE: To test whether rapid injection of rocuronium reduces withdrawal movement on injection. DESIGN: Randomized, prospective trial. SETTING: Operating room in a university hospital. PATIENTS: 150 ASA physical status I and II patients aged 18 to 60 years, undergoing general anesthesia. INTERVENTIONS: Patients were randomized to three groups. After undergoing anesthesia induction with thiopental sodium, then 5 seconds later receiving a rubber tourniquet applied to the mid-forearm to stop intravenous (IV) flow by gravity, the pretreatment drug was injected. The tourniquet was held for 15 seconds then released, and 1.0 mg/kg of 1% rocuronium was injected IV. Group C patients (n = 50) were pretreated with 0.1 mL/kg of 0.9% NaCl and then injected with rocuronium slowly within 10 seconds. Group L patients (n = 50) were pretreated with 0.1 mL/kg of preservative-free 1% lidocaine and then injected with rocuronium slowly within 10 seconds. Group R patients (n = 50) were pretreated with 0.1 mL/kg of 0.9% NaCl and then rapidly injected with rocuronium within approximately one second (as quickly as possible). MEASUREMENTS: After injection of the patient with the study drug, a single anesthesiologist with no knowledge of the study protocol graded each patient's response as follows: 0 = no response; 1 = mild movement limited to the wrist only; 2 = moderate movement involving the elbow and shoulder; and 3 = severe movement involving more than one extremity. MAIN RESULTS: Group C had the most intense and frequent withdrawal response. The frequency and intensity of withdrawal movement was significantly less in Groups L and R than Group C. No significant difference in withdrawal response between Groups L and R was noted. CONCLUSIONS: Withdrawal response can be significantly reduced for rocuronium injection without lidocaine pretreatment, simply through rapid injection. |
| | |
Authors:
|
Yong Cheol Lee; Young Ho Jang; Jin Mo Kim; Sang Gyu Lee |
Related Documents
:
|
12269876 - Efficacy and safety of botulinum toxin type a in the treatment of palmar hyperhidrosis:... 2259946 - Botulinum toxin in the treatment of hemifacial spasm. 18199956 - Longitudinal results with intratympanic dexamethasone in the treatment of ménière's d... 19835236 - Botox treatment for migraine and chronic daily headache in adolescents. 23588546 - Free vascularized fibular grafting benefits severely collapsed femoral head in concomit... 23263396 - Use of a silver-containing hydrofiber dressing for filling abscess cavity following inc... |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of clinical anesthesia Volume: 21 ISSN: 1873-4529 ISO Abbreviation: J Clin Anesth Publication Date: 2009 Sep |
Date Detail:
|
Created Date: 2009-10-16 Completed Date: 2010-01-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8812166 Medline TA: J Clin Anesth Country: United States |
Other Details:
|
Languages: eng Pagination: 427-30 Citation Subset: IM |
Affiliation:
|
Department of Anesthesiology and Pain Medicine, Keimyung University, School of Medicine, Joong-gu, Daegu 700-712, Korea. yclee@dsmc.or.kr |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Androstanols / administration & dosage*, adverse effects Anesthetics, Intravenous / therapeutic use Anesthetics, Local / therapeutic use Female Hospitals, University Humans Injections, Intravenous Lidocaine / therapeutic use* Male Middle Aged Movement / drug effects Neuromuscular Nondepolarizing Agents / administration & dosage*, adverse effects Pain / chemically induced, prevention & control* Prospective Studies Sodium Chloride / administration & dosage Thiopental / therapeutic use Tourniquets Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Androstanols; 0/Anesthetics, Intravenous; 0/Anesthetics, Local; 0/Neuromuscular Nondepolarizing Agents; 137-58-6/Lidocaine; 143558-00-3/rocuronium; 76-75-5/Thiopental; 7647-14-5/Sodium Chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Restoration of pulmonary compliance after laparoscopic surgery using a simple alveolar recruitment m...
Next Document: Does bilateral bispectral index monitoring (BIS) detect the discrepancy of cerebral reperfusion duri...