Document Detail

Rapid injection of rocuronium reduces withdrawal movement on injection.
MedLine Citation:
PMID:  19833276     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVE: To test whether rapid injection of rocuronium reduces withdrawal movement on injection. DESIGN: Randomized, prospective trial. SETTING: Operating room in a university hospital. PATIENTS: 150 ASA physical status I and II patients aged 18 to 60 years, undergoing general anesthesia. INTERVENTIONS: Patients were randomized to three groups. After undergoing anesthesia induction with thiopental sodium, then 5 seconds later receiving a rubber tourniquet applied to the mid-forearm to stop intravenous (IV) flow by gravity, the pretreatment drug was injected. The tourniquet was held for 15 seconds then released, and 1.0 mg/kg of 1% rocuronium was injected IV. Group C patients (n = 50) were pretreated with 0.1 mL/kg of 0.9% NaCl and then injected with rocuronium slowly within 10 seconds. Group L patients (n = 50) were pretreated with 0.1 mL/kg of preservative-free 1% lidocaine and then injected with rocuronium slowly within 10 seconds. Group R patients (n = 50) were pretreated with 0.1 mL/kg of 0.9% NaCl and then rapidly injected with rocuronium within approximately one second (as quickly as possible). MEASUREMENTS: After injection of the patient with the study drug, a single anesthesiologist with no knowledge of the study protocol graded each patient's response as follows: 0 = no response; 1 = mild movement limited to the wrist only; 2 = moderate movement involving the elbow and shoulder; and 3 = severe movement involving more than one extremity. MAIN RESULTS: Group C had the most intense and frequent withdrawal response. The frequency and intensity of withdrawal movement was significantly less in Groups L and R than Group C. No significant difference in withdrawal response between Groups L and R was noted. CONCLUSIONS: Withdrawal response can be significantly reduced for rocuronium injection without lidocaine pretreatment, simply through rapid injection.
Yong Cheol Lee; Young Ho Jang; Jin Mo Kim; Sang Gyu Lee
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical anesthesia     Volume:  21     ISSN:  1873-4529     ISO Abbreviation:  J Clin Anesth     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-10-16     Completed Date:  2010-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8812166     Medline TA:  J Clin Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  427-30     Citation Subset:  IM    
Department of Anesthesiology and Pain Medicine, Keimyung University, School of Medicine, Joong-gu, Daegu 700-712, Korea.
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MeSH Terms
Androstanols / administration & dosage*,  adverse effects
Anesthetics, Intravenous / therapeutic use
Anesthetics, Local / therapeutic use
Hospitals, University
Injections, Intravenous
Lidocaine / therapeutic use*
Middle Aged
Movement / drug effects
Neuromuscular Nondepolarizing Agents / administration & dosage*,  adverse effects
Pain / chemically induced,  prevention & control*
Prospective Studies
Sodium Chloride / administration & dosage
Thiopental / therapeutic use
Young Adult
Reg. No./Substance:
0/Androstanols; 0/Anesthetics, Intravenous; 0/Anesthetics, Local; 0/Neuromuscular Nondepolarizing Agents; 137-58-6/Lidocaine; 143558-00-3/rocuronium; 76-75-5/Thiopental; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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