| Rapid infusion of sodium bicarbonate and albumin into high-risk premature infants soon after birth: a controlled, prospective trial. | |
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MedLine Citation:
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PMID: 2013 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We conducted a controlled, prospective trial to evaluate the effectiveness of rapidly infusing sodium bicarbonate (NaHCO3) and salt-poor albumin into high-risk, premature infants in the first 2 hours of life. Fifty-three infants, randomized into one of four treatment groups, received 8 ml. per kilogram of a solution containing either (A) glucose in water, (B) salt-poor albumin, (C) NaHCO3, or (D) a combination of albumin and NaHCO3. After the initial infusion, the babies received no colloid or alkali solutions until 4 hours of age. We managed them supportively with warmth, appropriate oxygen administration, isotonic fluid infusion, and close monitoring. Among the infants who received alkali, 14 of 26 acquired the respiratory distress syndrome (RDS), 11 died, and four had intracranial hemorrhage. Among babies who received no alkali, RDS occurred in 11 of 27, 5 died, and none had intracranial hemorrhage. These results do not support the common practice of rapidly infusing NaHCO3 into high-risk, premature infants, and they suggest that the early management of such infants needs renewed critical evaluation. |
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Authors:
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R D Bland; T L Clarke; L B Harden |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 124 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1976 Feb |
Date Detail:
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Created Date: 1976-03-30 Completed Date: 1976-03-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 263-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acidosis
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drug therapy* Albumins / administration & dosage, therapeutic use* Bicarbonates / administration & dosage, therapeutic use* Carbon Dioxide / blood Cerebral Hemorrhage / mortality Female Hawaii Humans Hydrogen-Ion Concentration Infant, Newborn Infant, Premature, Diseases / blood, drug therapy*, mortality Infusions, Parenteral Male Prospective Studies Respiratory Distress Syndrome, Newborn / mortality Sodium / administration & dosage, therapeutic use* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Bicarbonates; 124-38-9/Carbon Dioxide; 7440-23-5/Sodium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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