| A rapid infusion protocol is safe for total dose iron polymaltose: time for change. | |
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MedLine Citation:
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PMID: 21040319 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Intravenous correction of iron deficiency by total dose iron polymaltose is inexpensive and safe, but current protocols entail prolonged administration over more than 4 h. This results in reduced patient acceptance, and hospital resource strain. We aimed to assess prospectively the safety of a rapid intravenous protocol and compare this with historical controls. Methods: Consecutive patients in whom intravenous iron replacement was indicated were invited to have up to 1.5 g iron polymaltose by a 58-min infusion protocol after an initial 15-min test dose without pre-medication. Infusion-related adverse events (AE) and delayed AE over the ensuing 5 days were also prospectively documented and graded as mild, moderate or severe. Results: One hundred patients, 63 female, mean age 54 (range 18-85) years were studied. Thirty-four infusion-related AE to iron polymaltose occurred in a total of 24 patients - 25 mild, 8 moderate and 1 severe; higher than previously reported for a slow protocol iron infusion. Thirty-one delayed AE occurred in 26 patients - 26 mild, 3 moderate and 2 severe; similar to previously reported. All but five patients reported they would prefer iron replacement through the rapid protocol again. The presence of inflammatory bowel disease (IBD) predicted infusion-related reactions (54% vs 14% without IBD, P < 0.001) and the serum C-reactive protein was higher in those with reactions (P= 0.043). Conclusion: Iron polymaltose can be successfully administered using a rapid total dose infusion protocol and was well accepted by patients. It offers significant cost, resource utilization and time benefits for the patient and hospital system. |
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Authors:
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M Garg; G Morrison; A Friedman; A Lau; D Lau; P R Gibson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Internal medicine journal Volume: 41 ISSN: 1445-5994 ISO Abbreviation: Intern Med J Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-07-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101092952 Medline TA: Intern Med J Country: Australia |
Other Details:
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Languages: eng Pagination: 548-54 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Internal Medicine Journal © 2011 Royal Australasian College of Physicians. |
Affiliation:
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Department of Gastroenterology and Hepatology, Eastern Health Department of Gastroenterology, Frankston Hospital Pharmacy Directorate, Eastern Health Monash University Department of Medicine, Eastern Health Clinical School, Melbourne, Victoria, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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