| Rapid increase in myocardial infarction risk following diagnosis of rheumatoid arthritis amongst patients diagnosed between 1995 and 2006. | |
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MedLine Citation:
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PMID: 20698926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the risk of MI and other IHD events amongst patients diagnosed with RA during the last decade and within 18 months following RA symptom onset, compared to the general population, by time since RA diagnosis, year of RA diagnosis and by rheumatoid factor (RF) status. METHODS AND PATIENTS: A Swedish inception cohort of RA (n = 7469) diagnosed between 1995 and 2006 and a matched general population comparator cohort (n = 37,024), was identified and linked to national registers of morbidity and mortality from IHD. Relative risks (RRs) of MI and other IHD events were estimated using Cox regression. RESULTS: During follow-up, 233 patients with RA and 701 controls developed a first MI, corresponding to an overall RR of MI of 1.6 (95% confidence interval 1.4, 1.9). Increased risks of MI were already detected within 1-4 years following RA diagnosis, as well as in patients diagnosed with RA during the last 5 years, in RF-negative patients and for transmural as well as nontransmural MIs. CONCLUSIONS: MI risk increases rapidly following RA diagnosis, suggesting the importance of additional mechanisms other than atherosclerosis. The elevated short-term risk is present amongst patients diagnosed in recent years, underscoring the importance of MI prevention from the time of RA diagnosis. |
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Authors:
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M E Holmqvist; S Wedrén; L T H Jacobsson; L Klareskog; F Nyberg; S Rantapää-Dahlqvist; L Alfredsson; J Askling |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of internal medicine Volume: 268 ISSN: 1365-2796 ISO Abbreviation: J. Intern. Med. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2011-01-14 Revised Date: 2011-06-13 |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: England |
Other Details:
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Languages: eng Pagination: 578-85 Citation Subset: IM |
Copyright Information:
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© 2010 The Association for the Publication of the Journal of Internal Medicine. |
Affiliation:
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Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. marie.holmqvist@ki.se |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Aged Aged, 80 and over Arthritis, Rheumatoid / complications*, epidemiology, immunology Epidemiologic Methods Female Hospitalization / statistics & numerical data Humans Male Middle Aged Myocardial Infarction / complications*, epidemiology Rheumatoid Factor / blood Sweden / epidemiology Time Factors |
| Chemical | |
Reg. No./Substance:
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9009-79-4/Rheumatoid Factor |
| Comments/Corrections | |
Comment In:
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J Intern Med. 2010 Dec;268(6):552-4
[PMID:
21054586
]
Expert Rev Cardiovasc Ther. 2011 Apr;9(4):429-32 [PMID: 21517727 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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