Document Detail


Rapid improvement in abnormal pulmonary epithelial permeability after stopping cigarettes.
MedLine Citation:
PMID:  6788126     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new, non-invasive method of measuring pulmonary epithelial damage in man was compared with traditional tests of small-airway function. Pulmonary epithelial permeability was expressed as the half-time clearance from the lung into blood of (99m)Tc-diethylene triaminepenta-acetic acid ((99m)Tc-DTPA) deposited predominantly in the alveoli from an inhaled aerosol.Recovery from abnormal pulmonary permeability was recorded after stopping smoking for 21 days in a group of young symptomless cigarette smokers. Before stopping smoking there was a significant correlation between half-time lung clearance of (99m)Tc-DTPA and carboxyhaemoglobin concentration (r=0.69; p <0.05). There was no correlation between carboxyhaemoglobin value and closing volume, the only other abnormal test of airway function. Twenty-four hours after stopping smoking the mean half-time lung clearance of (99m)Tc-DTPA had increased significantly (p <0.001) from a baseline of 15.8 min (SEM 1.3 min) to 25.5 min (SEM 2.5 min). The mean half-time clearance continued to increase to a maximum of 35.5 min (SEM 3.1 min) at seven days, but was significantly less than the reported half-time clearance for non-smokers (59 min, SEM
Authors:
B D Minty; C Jordan; J G Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal (Clinical research ed.)     Volume:  282     ISSN:  0267-0623     ISO Abbreviation:  Br Med J (Clin Res Ed)     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-09-22     Completed Date:  1981-09-22     Revised Date:  2010-10-26    
Medline Journal Info:
Nlm Unique ID:  8302911     Medline TA:  Br Med J (Clin Res Ed)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1183-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Carboxyhemoglobin / analysis
Epithelium / physiopathology
Humans
Lung / physiopathology*
Male
Pentetic Acid / diagnostic use
Permeability
Pulmonary Alveoli / physiopathology
Respiratory Function Tests
Smoking*
Technetium / diagnostic use
Chemical
Reg. No./Substance:
67-43-6/Pentetic Acid; 7440-26-8/Technetium; 9061-29-4/Carboxyhemoglobin
Comments/Corrections

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