Document Detail


Rapid high-pressure liquid chromatographic determination of quinidine and dihydroquinidine in plasma samples.
MedLine Citation:
PMID:  621655     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A high-pressure liquid chromatographic assay for quinidine and dihydroquinidine was developed. A cation-exchange column was utilized with an eluting solvent pH of about 9. The internal standard was cinchonine. The reproducibility and precision of this method were evaluated by analyzing replicate samples and by comparing results with those obtained from a TLC-fluorometric procedure. In addition, several drugs were evaluated to ascertain whether they interfered with the analysis of quinidine and dihydroquinidine.
Authors:
R E Kates; D W McKennon; T J Comstock
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  67     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-03-21     Completed Date:  1978-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  269-70     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromatography, High Pressure Liquid / methods
Humans
Quinidine / analogs & derivatives*,  blood*
Chemical
Reg. No./Substance:
56-54-2/Quinidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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