| Rapid glycosylations under extremely mild acidic conditions. Use of ammonium salts to activate glycosyl phosphites via P-protonation. | |
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MedLine Citation:
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PMID: 20435299 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Trifluoromethanesulfonic acid salts of tertiary amines were employed as extremely mild acidic activators for rapid glycosylations. Glycosyl phosphite triesters bearing an acid-labile 4,4'-dimethoxytrityl (DMTr) group for transient protection worked as glycosyl donors effectively in the presence of the activators to afford the corresponding disaccharides in good yields without loss of the DMTr group. |
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Authors:
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Fumiko Matsumura; Shiro Tatsumi; Natsuhisa Oka; Takeshi Wada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-04-03 |
Journal Detail:
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Title: Carbohydrate research Volume: 345 ISSN: 1873-426X ISO Abbreviation: Carbohydr. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-09-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0043535 Medline TA: Carbohydr Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1211-5 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Bioscience Building 702, 5-1-5 Kashiwanoha, Kashiwa, Chiba, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Glycosylation Hydrogen-Ion Concentration Kinetics Phosphites / chemistry* Phosphorus / chemistry* Protons* Quaternary Ammonium Compounds / chemistry* Salts / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Phosphites; 0/Protons; 0/Quaternary Ammonium Compounds; 0/Salts; 7723-14-0/Phosphorus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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