Document Detail


Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol.
MedLine Citation:
PMID:  22095466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: We have established a rapid and efficient differentiation protocol that is able to generate functional hepatocyte-like cells from human iPSCs. This may offer an alternative option for treatment of liver diseases.
Authors:
Yu-Fan Chen; Chien-Yu Tseng; Hsei-Wei Wang; Hung-Chih Kuo; Vincent W Yang; Oscar K Lee
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-01
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  55     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-30     Completed Date:  2012-05-22     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1193-203     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Association for the Study of Liver Diseases.
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Tetrachloride / adverse effects
Cell Differentiation / drug effects,  physiology*
Cell Lineage*
Cell Transplantation / methods*
Cells, Cultured
Disease Models, Animal
Gene Expression Profiling
Glutamine / pharmacology
Hepatocyte Growth Factor / pharmacology
Hepatocytes / cytology*,  physiology,  transplantation
Humans
Liver Failure / chemically induced,  therapy
Mice
Mice, SCID
Oncostatin M / pharmacology
Pluripotent Stem Cells / cytology*,  physiology
Treatment Outcome
Grant Support
ID/Acronym/Agency:
R01 CA084197/CA/NCI NIH HHS; R01 DK052230/DK/NIDDK NIH HHS; R01 DK093680/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0RH81L854J/Glutamine; 106956-32-5/Oncostatin M; 67256-21-7/Hepatocyte Growth Factor; CL2T97X0V0/Carbon Tetrachloride
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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