Document Detail


Rapid gastric emptying, rather than delayed gastric emptying, might provoke functional dyspepsia.
MedLine Citation:
PMID:  21443715     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
It has been suggested that there could be three possible mechanisms of gastric dysfunction in patients with FD: (i) delayed gastric emptying, (ii) impaired gastric accommodation of food intake, and (iii) hypersensitivity to gastric distention. Postprandial fullness seems to be the most severe symptom in patients who report aggravation of their symptoms after meals. Therefore, it has been assumed that delayed gastric emptying and consequent prolonged antral distension could reduce hunger, increase satiety, and even cause gastric discomfort, all of which would pose a significant barrier to adequate nutrition. We previously reported that postprandial water intake inhibits gastric antral motility along with an increase of cholecystokinin (CCK) in normal subjects. We assumed that the rapid increase of CCK after water intake was initiated by a feedback mechanism related to the inflow of fatty chyme into the duodenum that inhibits gastric antral activity. This duodeno-gastric interaction is known as the "duodenal break." We also reported that total gastric emptying was more rapid after the intake of a high-viscosity liquid meal than after a low-viscosity meal, because the low-viscosity liquid meal inhibits gastric emptying after rapid initial inflow into the duodenum. Considering these results, we hypothesized that rapid gastric emptying, rather than delayed gastric emptying, could be a cause of FD. In some patients with postprandial distress syndrome (PDS), we have found a significant correspondence between PDS-related dyspepsia and accelerated gastric emptying in the early postprandial period. It is worth emphasizing that the duodenum and the duodeno-gastric interaction (duodenal break) could have an important role in the pathophysiology of FD. We consider that rapid gastric emptying might be a more important factor than delayed gastric emptying in patients with FD.
Authors:
Motoyasu Kusano; Hiroaki Zai; Yasuyuki Shimoyama; Hiroko Hosaka; Shikou Kuribayashi; Osamu Kawamura; Masatomo Mori
Related Documents :
16792065 - Validation of a microwell dna probe assay for detection of listeria spp. in foods perfo...
16033505 - Microbiological survey of prepackaged pâté and ham in new zealand.
19278345 - Lmo0038 is involved in acid and heat stress responses and specific for listeria monocyt...
15644105 - Performance of a new chromogenic plating medium for the isolation of listeria monocytog...
9100605 - Ramadan diet restrictions modify the circadian time structure in humans. a study on pla...
14131355 - Enhancing effect of feces on isolation of salmonellae from selenite broth.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastroenterology and hepatology     Volume:  26 Suppl 3     ISSN:  1440-1746     ISO Abbreviation:  J. Gastroenterol. Hepatol.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8607909     Medline TA:  J Gastroenterol Hepatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  75-8     Citation Subset:  IM    
Copyright Information:
© 2011 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd.
Affiliation:
Department of Endoscopy and Endoscopic Surgery, Gunma University Hospital, Maebashi, Gunma, Japan. mkusano@showa.gunma-u.ac.jp
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Ghrelin family of peptides and gut motility.
Next Document:  An audit of combined multichannel intraluminal impedance manometry in the assessment of dysphagia.