Document Detail

Rapid filopodial sprouting induced by electrical stimulation in nerve terminals.
MedLine Citation:
PMID:  8271498     Owner:  NLM     Status:  MEDLINE    
Direct electrical stimulation of terminals of neurite-like extensions of cultured chromaffin cells and neuronally differentiated PC12 cells induced rapid sprouting of filopodia in a Ca dependent manner. Repetitive stimulation could produce filopodia with greater ease. Their formation could not be significantly suppressed by treatment with cytoskeletal blocking agents. Filopodial sprouting was localized to the terminal region only. This response may occur at the growth cone in vivo playing a role in neuronal development.
S Manivannan; S Terakawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  43 Suppl 1     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  1993  
Date Detail:
Created Date:  1994-02-03     Completed Date:  1994-02-03     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  S217-20     Citation Subset:  IM    
Department of Cell Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
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MeSH Terms
Calcium Chloride / pharmacology
Cells, Cultured
Electric Stimulation
Enterochromaffin Cells / drug effects,  physiology,  ultrastructure
Image Processing, Computer-Assisted
Nerve Endings / drug effects,  physiology*,  ultrastructure
Neurites / physiology*,  ultrastructure
PC12 Cells
Reg. No./Substance:
10043-52-4/Calcium Chloride

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