Document Detail

Rapid fabrication of nickel molds for prototyping embossed plastic microfluidic devices.
MedLine Citation:
PMID:  23450308     Owner:  NLM     Status:  MEDLINE    
The production of hot embossed plastic microfluidic devices is demonstrated in 1-2 h by exploiting vinyl adhesive stickers as masks for electroplating nickel molds. The sticker masks are cut directly from a CAD design using a cutting plotter and transferred to steel wafers for nickel electroplating. The resulting nickel molds are used to hot emboss a variety of plastic substrates, including cyclo-olefin copolymer and THV fluorinated thermoplastic elastomer. Completed devices are formed by bonding a blank sheet to the embossed layer using a solvent-assisted lamination method. For example, a microfluidic valve array or automaton and a droplet generator were fabricated with less than 100 μm x-y plane feature resolution, to within 9% of the target height, and with 90 ± 11% height uniformity over 5 cm. This approach for mold fabrication, embossing, and bonding reduces fabrication time and cost for research applications by avoiding photoresists, lithography masks, and the cleanroom.
Richard Novak; Navpreet Ranu; Richard A Mathies
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Lab on a chip     Volume:  13     ISSN:  1473-0189     ISO Abbreviation:  Lab Chip     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-19     Completed Date:  2013-09-10     Revised Date:  2014-04-22    
Medline Journal Info:
Nlm Unique ID:  101128948     Medline TA:  Lab Chip     Country:  England    
Other Details:
Languages:  eng     Pagination:  1468-71     Citation Subset:  IM    
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MeSH Terms
Alkenes / chemistry
Computer-Aided Design
DNA / analysis
Microfluidic Analytical Techniques / instrumentation*,  methods
Nickel / chemistry*
Polymerase Chain Reaction
Polymers / chemistry
Single-Cell Analysis
Grant Support
Reg. No./Substance:
0/Alkenes; 0/Polymers; 7OV03QG267/Nickel; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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