Document Detail


Rapid eye movement-related brain activation in human sleep: a functional magnetic resonance imaging study.
MedLine Citation:
PMID:  15891584     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In animal models, ponto-geniculo-occipital waves appear as an early sign of rapid eye movement sleep and may be functionally significant for brain plasticity processes. In this pilot study, we use a combined polysomnographic and functional magnetic resonance imaging approach, and show distinct magnetic resonance imaging signal increases in the posterior thalamus and occipital cortex in close temporal relationship to rapid eye movements during human rapid eye movement sleep. These findings are consistent with cell recordings in animal experiments and demonstrate that functional magnetic resonance imaging can be utilized to detect ponto-geniculo-occipital-like activity in humans. Studying intact neuronal networks underlying sleep regulation is no longer confined to animal models, but has been shown to be feasible in humans by a combined functional magnetic resonance imaging and electroencephalograph approach.
Authors:
Renate Wehrle; Michael Czisch; Christian Kaufmann; Thomas C Wetter; Florian Holsboer; Dorothee P Auer; Thomas Pollmächer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  16     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-13     Completed Date:  2005-08-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  853-7     Citation Subset:  IM    
Affiliation:
Max Planck Institute of Psychiatry, Kraepelinstr. 10, D-80804 Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Mapping
Chin / physiology
Electroencephalography / methods
Electromyography / methods
Female
Humans
Image Processing, Computer-Assisted / methods
Magnetic Resonance Imaging / methods*
Male
Occipital Lobe / blood supply*,  physiology
Oxygen / blood
Pilot Projects
Polysomnography / methods
Sleep / physiology*
Sleep, REM / physiology*
Thalamus / blood supply*,  physiology
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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