Document Detail

Rapid expression of the Na(+)-Ca2+ exchanger in response to cardiac pressure overload.
MedLine Citation:
PMID:  8214109     Owner:  NLM     Status:  MEDLINE    
This report identifies a rapid increase in the expression of cardiac Na(+)-Ca2+ exchanger mRNA in response to an acute pressure overload. This enhanced exchanger expression appeared within 1 h after the onset of right ventricular pressure overload in the cat and was sustained during cardiac overloading for at least 4 h. Maintenance of this right ventricular pressure overload for 48 h evoked an increase in the production of exchanger protein. Because of our previous finding that load imposition on the heart initiates cell growth and our hypothesis that this is in response to the enhanced entry of cellular cations, we then examined the effect of Na+ influx into cultured adult cardiac myocytes, or cardiocytes, in terms of early anabolic responses. Pressure overload of the heart and cardiocyte Na+ influx were found to produce a common, rapid result in terms of both enhanced Na(+)-Ca2+ exchanger expression and accelerated synthesis of general and contractile proteins, the hallmarks of cardiac hypertrophy.
R L Kent; J D Rozich; P L McCollam; D E McDermott; U F Thacker; D R Menick; P J McDermott; G Cooper
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  265     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1993 Sep 
Date Detail:
Created Date:  1993-11-22     Completed Date:  1993-11-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1024-9     Citation Subset:  IM    
Gazes Cardiac Research Institute, Department of Medicine, Medical University of South Carolina, Charleston.
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MeSH Terms
Carrier Proteins / genetics,  metabolism*
Cells, Cultured
Heart / physiopathology
Heart Ventricles
Hypertension / genetics,  metabolism*,  pathology
Myocardium / metabolism*,  pathology
RNA, Messenger / metabolism
Sodium / metabolism
Sodium-Calcium Exchanger
Time Factors
Grant Support
Reg. No./Substance:
0/Carrier Proteins; 0/RNA, Messenger; 0/Sodium-Calcium Exchanger; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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