Document Detail


Rapid enantiomeric quantification of an antiviral nucleoside agent (D,L-FMAU, 2'-fluoro-5-methyl-beta,D,L-arabinofurano-syluracil) by mass spectrometry.
MedLine Citation:
PMID:  11606118     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel mass spectrometric method is applied to rapid, accurate (<1%) quantification of chiral Clevudine (L-FMAU, 2'-fluoro-5-methyl-beta,L-arabinofuranosyluracil), a potent antiviral nucleoside agent against hepatitis B virus. Transition metal bound complex ions containing the chiral drug are generated by electrospray ionization mass spectrometry and subjected to collision-induced dissociation. The ratio of the two competitive dissociation rates is related to the enantiomeric composition of the drug mixture, allowing the determination of enantiomeric contamination in the drug.
Authors:
W A Tao; L Wu; R G Cooks; F Wang; J A Begley; B Lampert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  44     ISSN:  0022-2623     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-18     Completed Date:  2001-12-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3541-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Antiviral Agents / chemistry*
Arabinofuranosyluracil / analogs & derivatives,  chemistry*
Spectrometry, Mass, Electrospray Ionization
Stereoisomerism
Chemical
Reg. No./Substance:
0/Antiviral Agents; 3083-77-0/Arabinofuranosyluracil; 69256-17-3/2'-fluoro-5-methylarabinosyluracil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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