| Rapid effects of hypoxia on the cerebrospinal fluid levels of adenosine and related metabolites in newborn and one-month-old piglets. | |
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MedLine Citation:
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PMID: 2015327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of hypoxia on the levels of adenosine, inosine and hypoxanthine in the cerebrospinal fluid (CSF) was determined by HPLC in newborn (1- to 3-day-old, n = 6) and 1-month-old (n = 5) piglets. Serial CSF samples (q 60 s) were obtained from the cisterna magna during normoxia and a 5-min hypoxia test (PaO2 = 26.5 +/- 2.9 Torr). In normoxia, newborns had a lower mean (+/- SEM) CSF concentration of adenosine (0.72 +/- 0.17 vs 2.60 +/- 0.44 microM) and a higher concentration of hypoxanthine (4.88 +/- 0.41 vs. 1.39 +/- 0.60 microM) than the mature piglets (p less than 0.05). In all animals, hypoxia induced an increase in CSF levels of adenosine and its metabolites between 2 and 4 min. However, peak adenosine concentrations were higher in mature (4.17 +/- 1.41 microM) than in newborn (1.55 +/- 0.29 microM) piglets (p less than 0.05). These data might explain deficient vasodilator adaptation required for neonatal CBF regulation. |
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Authors:
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N Laudignon; E Farri; K Beharry; J V Aranda |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biology of the neonate Volume: 59 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 1991 |
Date Detail:
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Created Date: 1991-05-17 Completed Date: 1991-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 54-9 Citation Subset: IM |
Affiliation:
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Developmental Pharmacology and Perinatal Research Unit, McGill University, Montreal, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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cerebrospinal fluid*,
metabolism Aging / physiology* Animals Animals, Newborn Anoxia / metabolism* Blood Gas Analysis Hypoxanthine Hypoxanthines / metabolism* Inosine / metabolism* Swine |
| Chemical | |
Reg. No./Substance:
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0/Hypoxanthines; 58-61-7/Adenosine; 58-63-9/Inosine; 68-94-0/Hypoxanthine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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