Document Detail


Rapid dopamine dynamics in the accumbens core and shell: learning and action.
MedLine Citation:
PMID:  23276989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The catecholamine dopamine (DA) has been implicated in a host of neural processes as diverse as schizophrenia, parkinsonism and reward encoding. Importantly, these distinct features of DA function are due in large part to separate neural circuits involving connections arising from different DA-releasing nuclei and projections to separate afferent targets. Emerging data has suggested that this same principle of separate neural circuits may be applicable within structural subregions, such as the core and shell of the nucleus accumbens (NAc). Further, DA may act selectively on smaller ensembles of cells (or, microcircuits) via differential DA receptor density and distinct inputs and outputs of the microcircuits, thus enabling new learning about Pavlovian cues, instrumental responses, subjective reward processing and decision-making. In this review, by taking advantage of studies using subsecond voltammetric techniques in behaving animals to study how rapid changes in DA levels affect behavior, we examine the spatial and temporal features of DA release and how it relates to both normal learning and similarities to pathological learning in the form of addiction.
Authors:
Michael P Saddoris; Jonathan A Sugam; Fabio Cacciapaglia; Regina M Carelli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Elite edition)     Volume:  5     ISSN:  1945-0508     ISO Abbreviation:  Front Biosci (Elite Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  2013-06-05     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101485240     Medline TA:  Front Biosci (Elite Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-88     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Decision Making / physiology*
Dopamine / metabolism*
Dopaminergic Neurons / metabolism*
Humans
Learning / physiology*
Motivation / physiology*
Nucleus Accumbens / metabolism,  physiology*
Reward*
Grant Support
ID/Acronym/Agency:
DA 017318/DA/NIDA NIH HHS; DA 029156/DA/NIDA NIH HHS; DA 030307/DA/NIDA NIH HHS; F31 DA030307/DA/NIDA NIH HHS; F32 DA028156/DA/NIDA NIH HHS; R01 DA017318/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
E78ZFF4KQ0/Reward; VTD58H1Z2X/Dopamine
Comments/Corrections

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