Document Detail


Rapid diagnosis of invasive aspergillosis by antigen detection.
MedLine Citation:
PMID:  14987199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aspergillosis is a serious and often fatal infection in the bone marrow or organ transplant patient, for which improved methods of diagnosis are desperately needed. Currently, the diagnosis is most often made based on clinical findings and radiographic findings, which are nonspecific, and toxic therapies are initiated empirically, often without ever establishing the diagnosis. Without a definitive diagnosis, physicians often withhold or reduce the doses of the antifungal agent when toxicity develops or the patient improves, permitting progression of disease in those with invasive aspergillosis. The Platelia Aspergillus galactomannan antigenemia assay may assist physicians in making these decisions. With a sensitivity of 81% and a specificity of 89% in the studies leading to its FDA clearance, physicians still must be aware of the potential for false-positive and false-negative results; the test does not replace careful microbiological and clinical evaluation. This report will review the relevant literature and provide guidelines for use of the test in patient management.
Authors:
L J Wheat
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Transplant infectious disease : an official journal of the Transplantation Society     Volume:  5     ISSN:  1398-2273     ISO Abbreviation:  Transpl Infect Dis     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-02-27     Completed Date:  2004-05-19     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100883688     Medline TA:  Transpl Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  158-66     Citation Subset:  IM    
Affiliation:
MiraVista Diagnostics and MiraBella Technologies Indianapolis, Indiana 46241, USA. jwheat@miravistalabs.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Fungal / analysis*,  blood
Aspergillosis / diagnosis*
Humans
Immunoenzyme Techniques
Polymerase Chain Reaction
Sensitivity and Specificity
Chemical
Reg. No./Substance:
0/Antigens, Fungal
Comments/Corrections
Comment In:
Transpl Infect Dis. 2003 Dec;5(4):157   [PMID:  14987198 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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