| Rapid diagnosis of invasive aspergillosis by antigen detection. | |
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MedLine Citation:
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PMID: 14987199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aspergillosis is a serious and often fatal infection in the bone marrow or organ transplant patient, for which improved methods of diagnosis are desperately needed. Currently, the diagnosis is most often made based on clinical findings and radiographic findings, which are nonspecific, and toxic therapies are initiated empirically, often without ever establishing the diagnosis. Without a definitive diagnosis, physicians often withhold or reduce the doses of the antifungal agent when toxicity develops or the patient improves, permitting progression of disease in those with invasive aspergillosis. The Platelia Aspergillus galactomannan antigenemia assay may assist physicians in making these decisions. With a sensitivity of 81% and a specificity of 89% in the studies leading to its FDA clearance, physicians still must be aware of the potential for false-positive and false-negative results; the test does not replace careful microbiological and clinical evaluation. This report will review the relevant literature and provide guidelines for use of the test in patient management. |
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Authors:
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L J Wheat |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Transplant infectious disease : an official journal of the Transplantation Society Volume: 5 ISSN: 1398-2273 ISO Abbreviation: Transpl Infect Dis Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2004-02-27 Completed Date: 2004-05-19 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 100883688 Medline TA: Transpl Infect Dis Country: Sweden |
Other Details:
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Languages: eng Pagination: 158-66 Citation Subset: IM |
Affiliation:
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MiraVista Diagnostics and MiraBella Technologies Indianapolis, Indiana 46241, USA. jwheat@miravistalabs.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigens, Fungal / analysis*, blood Aspergillosis / diagnosis* Humans Immunoenzyme Techniques Polymerase Chain Reaction Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Fungal |
| Comments/Corrections | |
Comment In:
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Transpl Infect Dis. 2003 Dec;5(4):157
[PMID:
14987198
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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