| Rapid dextran infusion in essential hypertension. | |
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MedLine Citation:
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PMID: 94313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hemodynamic parameters were studied before and after rapid dextran infusion in 34 men including 17 patients with sustained essential hypertension and 17 normotensive controls. In both groups of patients, dextran infusion induced a significant increase (p less than 0.001) in central venous pressure (CVP), cardiac output (CO), and stroke volume. The percent change in stroke volume was significantly higher in hypertensives (p less than 0.001) than in controls. Three indices of volume expansion were calculated: 1) the ratio between the change in CO and the change in volume, which was significantly higher in hypertensives (p less than 0.025), 2) the ratio between the change in CO and the change in CVP, which was similar in both groups, and 3) the ratio between the change in volume and the change in CVP, which was significantly reduced in hypertensives (p less than 0.001). In the overall population, the latter ratio was negatively correlated with the change in CO (or in stroke volume) induced by expansion ( r = -0.75). The results provided evidence that: 1) the slope of the relationship between CO and blood volume was steeper in hypertensives than in normotensives, and 2) the steeper slope was due to a reduction in the effective compliance of the vascular bed, causing a greater elevation in CO per unit rise in volume. |
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Authors:
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M E Safar; G M London; J A Levenson; A C Simon; N P Chau |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Hypertension Volume: 1 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1979 Nov-Dec |
Date Detail:
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Created Date: 1980-06-16 Completed Date: 1980-06-16 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 615-23 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure / drug effects Blood Volume / drug effects Cardiac Output / drug effects Dextrans / administration & dosage, pharmacology* Hemodynamics / drug effects Humans Hypertension / physiopathology* Infusions, Intra-Arterial Male Time Factors |
| Chemical | |
Reg. No./Substance:
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9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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