Document Detail

Rapid dextran infusion in essential hypertension.
MedLine Citation:
PMID:  94313     Owner:  NLM     Status:  MEDLINE    
Hemodynamic parameters were studied before and after rapid dextran infusion in 34 men including 17 patients with sustained essential hypertension and 17 normotensive controls. In both groups of patients, dextran infusion induced a significant increase (p less than 0.001) in central venous pressure (CVP), cardiac output (CO), and stroke volume. The percent change in stroke volume was significantly higher in hypertensives (p less than 0.001) than in controls. Three indices of volume expansion were calculated: 1) the ratio between the change in CO and the change in volume, which was significantly higher in hypertensives (p less than 0.025), 2) the ratio between the change in CO and the change in CVP, which was similar in both groups, and 3) the ratio between the change in volume and the change in CVP, which was significantly reduced in hypertensives (p less than 0.001). In the overall population, the latter ratio was negatively correlated with the change in CO (or in stroke volume) induced by expansion ( r = -0.75). The results provided evidence that: 1) the slope of the relationship between CO and blood volume was steeper in hypertensives than in normotensives, and 2) the steeper slope was due to a reduction in the effective compliance of the vascular bed, causing a greater elevation in CO per unit rise in volume.
M E Safar; G M London; J A Levenson; A C Simon; N P Chau
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  1     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:    1979 Nov-Dec
Date Detail:
Created Date:  1980-06-16     Completed Date:  1980-06-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  615-23     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Blood Volume / drug effects
Cardiac Output / drug effects
Dextrans / administration & dosage,  pharmacology*
Hemodynamics / drug effects
Hypertension / physiopathology*
Infusions, Intra-Arterial
Time Factors
Reg. No./Substance:

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