| Rapid development of a hepatocellular carcinoma in isolated thrombosis of hepatic veins (classic Budd-Chiari syndrome): case report and review of literature. | |
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MedLine Citation:
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PMID: 22125582 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Budd-Chiari syndrome and membranous obstruction of the inferior vena cava frequently result in the development of mostly benign hepatic lesions. In cases of membranous obstruction of the inferior vena cava, which is prevalent mostly in the East, these lesions often progress to hepatocellular carcinoma. In contrast, malignant transformation has not yet been recognised in patients with isolated hepatic vein thrombosis. We report the case of a 37-year-old male Caucasian who presented with acute Budd-Chiari syndrome without involvement of the inferior vena cava. Despite porto-caval shunting, a hepatocellular carcinoma developed within several months. Three hepatic lesions were treated by radiofrequency thermal ablation until liver transplantation was performed. This report emphasises the possibility of malignant transformation of regenerative nodules in patients with disturbed hepatic perfusion in general. Physicians must be aware of this when assessing regenerative nodules, especially as no unambiguous predictors for the development of hepatocellular carcinoma have been identified so far. |
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Authors:
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Jens Walldorf; Andrea Tannapfel; Hans Jürgen Holzhausen; Christian Wittekind; Thomas Seufferlein; Utz Settmacher; Wolfgang E Fleig; Matthias M Dollinger |
Publication Detail:
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Type: Journal Article Date: 2009-11-29 |
Journal Detail:
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Title: BMJ case reports Volume: 2009 ISSN: 1757-790X ISO Abbreviation: BMJ Case Rep Publication Date: 2009 |
Date Detail:
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Created Date: 2011-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101526291 Medline TA: BMJ Case Rep Country: England |
Other Details:
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Languages: eng Pagination: - Citation Subset: - |
Affiliation:
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University of Halle-Wittenberg, Department of Internal Medicine I, Ernst-Grube-Strasse 20, Halle, 06120, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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