Document Detail


Rapid decline in nuclear COP1 abundance anticipates the stabilisation of its target HY5 in the light.
MedLine Citation:
PMID:  24434030     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In darkness, the E3 ligase COSTITUTIVE PHOTOMORPHOGENESIS 1 (COP1) targets to degradation ELONGATED HYPOCOTYL 5 (HY5) and other proteins required for photomorphogenesis (Osterlund et al., 2000; Saijo et al., 2003; Seo et al., 2003). Light inactivates COP1, allowing photomorphogenesis to proceed (Lau and Deng, 2012). Pioneer studies have demonstrated that biologically active COP1-GUS fusion proteins migrate from the nucleus to the cytoplasm (von Arnim and Deng, 1994) but this shift is too slow to be the mechanism of COP1 inactivation involved in rapid light-induced responses (von Arnim et al., 1997; Lau and Deng, 2012). Here, we re-examine the latter conclusion by using YFP-COP1 and comparing the kinetics to that of nuclear HY5.
Authors:
Manuel Pacín; Martina Legris; Jorge Jose Casal
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-1-16
Journal Detail:
Title:  Plant physiology     Volume:  -     ISSN:  1532-2548     ISO Abbreviation:  Plant Physiol.     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401224     Medline TA:  Plant Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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