Document Detail

Rapid cooling for saving lives: a bioengineering opportunity.
MedLine Citation:
PMID:  17605679     Owner:  NLM     Status:  MEDLINE    
The induction of mild hypothermia, lowering body temperature by 4 degrees C, is gaining acceptance as an acute therapy for the treatment of hypoxia and ischemia following cardiac arrest and many life-threatening injuries. When hypothermia is used following ischemia (as opposed to before ischemia), it needs to be performed rapidly for the greatest benefit, preferably within 5 min. When we consider the basic heat-transfer problem and define the engineering parameter space, we find that almost 3900 W of cooling are required in order to achieve 4 degrees C cooling within 5 min. A simple model reveals that this poses a significant bioengineering challenge as the rate of heat transfer is severely limited, owing to a relatively confined fundamental parameter space. Current methods of cooling include external cooling devices, such as cooling blankets or ice bags, which are simple to use, relatively inexpensive but slow. Internal cooling has the best ability to cool more rapidly but current devices are more invasive, costly and most are still not able to provide cooling within the rapid 5-min interval. Cardiopulmonary bypass and recirculating coolants can achieve the cooling rate but are currently extremely invasive and require a highly skilled team to implement. Future therapies may include phase-change coolants, such as microparticulate ice-saline slurries or evaporative cooling technologies specifically designed for human use. With continuing research and investment, methods for rapid cooling can be developed and will translate into saving lives.
Joshua W Lampe; Lance B Becker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Expert review of medical devices     Volume:  4     ISSN:  1743-4440     ISO Abbreviation:  -     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-03     Completed Date:  2008-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230445     Medline TA:  Expert Rev Med Devices     Country:  England    
Other Details:
Languages:  eng     Pagination:  441-6     Citation Subset:  IM    
Center for Resuscitation Science, Department of Emergency Medicine, University of Pennsylvania Hospital; Philadelphia, USA.
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MeSH Terms
Biomedical Engineering / methods*,  trends
Body Temperature
Body Temperature Regulation
Hypothermia, Induced / instrumentation*,  methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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