Document Detail

Rapid collection of human intrinsic factor uncontaminated with cobalophilin (R binder).
MedLine Citation:
PMID:  3740028     Owner:  NLM     Status:  MEDLINE    
Intrinsic factor and R binder cobalamin binding capacity (CblBC) were measured in gastric juices obtained through feeding gastrostomy tubes (FG-GJ) from six patients with relatively complete obstruction to swallowing because of surgical resections for oropharyngeal or laryngeal carcinomas. Controls were six nonpernicious anemia gastric juices. In five of the six FG-GJ 97% of CblBC was intrinsic factor. In the sixth FG-GJ, with GJ pH = 7.2, in addition to intrinsic factor there was 22% nonintrinsic factor cobalamin-specific binder, which presumably represented partially degraded R binder refluxed from the duodenum. These data demonstrate that relatively "pure" intrinsic factor, i.e., uncontaminated with other cobalamin binders, can easily be obtained by simple drainage of FG-GJ. The study also supports evidence that gastric juice R binder is either swallowed or refluxed from the duodenum, and does not originate in the stomach.
B Herzlich; V Herbert
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  81     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  1986 Aug 
Date Detail:
Created Date:  1986-09-17     Completed Date:  1986-09-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  678-80     Citation Subset:  IM    
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MeSH Terms
Gastric Juice / analysis*
Gastric Mucosa / secretion
Intrinsic Factor / analysis*,  secretion
Intubation, Gastrointestinal
Pancreas / secretion
Transcobalamins / analysis*,  secretion
Grant Support
Reg. No./Substance:
0/Transcobalamins; 9008-12-2/Intrinsic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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