Document Detail

Rapid chylomicron appearance following sequential meals: effects of second meal composition.
MedLine Citation:
PMID:  9682661     Owner:  NLM     Status:  MEDLINE    
Previous studies have noted the presence of an early postprandial peak in plasma triacylglycerol concentrations following successive fat-rich meals. An earlier study has shown that the triacylglycerol in this early peak originates from a previous meal. The present study was performed to investigate the effects of different second meals on the plasma triacylglycerol response. Six healthy subjects were studied on four occasions each. At 5 h following a fat-rich breakfast they ingested one of the following in a balanced design: a fat-rich meal, a low-fat meal, water or nothing by mouth. Blood samples were taken for 2.5 h following the second meal. An early peak in chylomicron and plasma triacylglycerol concentrations was seen following both low-fat and fat-rich second meals but not following water. During studies investigating postprandial lipaemia, further meals must be avoided, even if they contain no fat, although water may be allowed.
K Evans; P J Kuusela; M L Cruz; I Wilhelmova; B A Fielding; K N Frayn
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  79     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-03     Completed Date:  1998-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  425-9     Citation Subset:  IM    
Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, Headington, Oxford, UK.
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MeSH Terms
Analysis of Variance
Chylomicrons / blood*
Dietary Fats / administration & dosage*
Eating / physiology*
Postprandial Period
Triglycerides / analysis,  metabolism*
Reg. No./Substance:
0/Chylomicrons; 0/Dietary Fats; 0/Triglycerides

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