| Rapid but not slow spinal cord compression elicits neurogenic pulmonary edema in the rat. | |
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MedLine Citation:
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PMID: 18380532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of neurogenic pulmonary edema (NPE) can be elicited by an immediate epidural balloon compression of the thoracic spinal cord. To evaluate whether a slower balloon inflation could prevent NPE development, we examined the extent of NPE in animals lesioned with a rapid (5 microl - 5 microl - 5 microl) or slow rate (3 microl - 2 microl - 2 microl - 2 microl - 2 microl - 2 microl - 2 microl) of balloon inflation. These groups were compared with the NPE model (immediate inflation to 15 microl) and with healthy controls. Slow balloon inflation prevented NPE development, whereas the pulmonary index and histology revealed a massive pulmonary edema in the group with a rapid rate of balloon inflation. Pulmonary edema was preceded by a considerable decrease in heart rate during the inflation procedure. Moreover, rapid inflation of balloon in spinal channel to either 5 microl or 10 microl did not cause NPE. Thus, a slow rate of balloon inflation in the thoracic epidural space prevents the development of neurogenic pulmonary edema, most likely due to the better adaptation of the organism to acute circulatory changes (rapid elevation of systemic blood pressure accompanied by profound heart rate reduction) during the longer balloon inflation period. It should be noted that spinal cord transection at the same level did not cause neurogenic pulmonary edema. |
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Authors:
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J Sedý; J Zicha; J Kunes; P Jendelová; E Syková |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-01 |
Journal Detail:
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Title: Physiological research / Academia Scientiarum Bohemoslovaca Volume: 58 ISSN: 0862-8408 ISO Abbreviation: Physiol Res Publication Date: 2009 |
Date Detail:
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Created Date: 2009-04-28 Completed Date: 2009-06-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9112413 Medline TA: Physiol Res Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 269-77 Citation Subset: IM |
Affiliation:
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Academy of Sciences of the Czech Republic, Prague, Czech Republic. jirisedy@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Balloon Dilatation / adverse effects, methods Blood Pressure Disease Models, Animal Epidural Space Heart Rate Male Pulmonary Alveoli / pathology, physiopathology Pulmonary Edema / etiology*, pathology, physiopathology* Rats Rats, Wistar Spinal Cord Compression / complications*, physiopathology* Spinal Cord Injuries / complications, physiopathology Thoracic Vertebrae Time Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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