Document Detail


Rapid brain cooling by hypothermic retrograde jugular vein flush.
MedLine Citation:
PMID:  15761354     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Although whole-body hypothermia recently has been reported effective in improving the neurologic outcome after cardiac arrest, it is contraindicated in the management of trauma patients with hemorrhagic shock. To provide selective brain cooling in this situation, the authors speculated about the feasibility of hypothermic retrograde jugular vein flush (HRJVF). This preliminary study was conducted to test the effectiveness of brain cooling after HRJVF in rats without hemorrhagic shock. METHODS: After jugular vein cannulation with cranial direction, Sprague-Dawley rats were randomized into a normal control group, a group that underwent flush with cold saline at 4 degrees C, or a group that underwent flush with saline at a room temperature of 24 degrees C. A Servo-controlled heat lamp was applied for all the rats to keep their rectal temperature at 37 +/- 0.5 degrees C. Their brain temperature and cerebral blood flow were checked. RESULTS: Within the 10-minute period of cold saline flush (1.7 mL/100 g), brain temperature was immediately decreased, and this cooling effect could be maintained for at least 20 minutes. Cerebral blood flow was significantly increased after HRJVF, then returned gradually to the baseline as brain temperature elevated. CONCLUSIONS: This study successfully demonstrated a significant cooling effect in rat brain by HRJVF. For preservation of brain function, HRJVF may be useful in resuscitation for trauma patients with hemorrhagic shock after further studies on animals with shock.
Authors:
Yi-Szu Wen; Mu-Shung Huang; Mao-Tsun Lin; Chen-Hsen Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of trauma     Volume:  58     ISSN:  0022-5282     ISO Abbreviation:  J Trauma     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-11     Completed Date:  2005-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  577-81     Citation Subset:  AIM; IM    
Affiliation:
Institute of Clinical Medicine, National Yang-Ming University, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Gas Analysis
Body Temperature
Brain*
Cerebrovascular Circulation
Disease Models, Animal
Feasibility Studies
Hematocrit
Hypothermia, Induced / instrumentation,  methods*
Irrigation / instrumentation,  methods*
Jugular Veins*
Male
Microdialysis / instrumentation
Models, Animal
Phlebotomy / methods
Random Allocation
Rats
Rats, Sprague-Dawley
Rectum
Resuscitation / methods
Sodium Chloride / therapeutic use*
Time Factors
Wounds and Injuries / therapy
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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