| Rapid behavioral response to corticosterone varies with photoperiod and dose. | |
| | |
MedLine Citation:
|
PMID: 10712855 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The magnitude of the adrenocortical response to stress can be modulated by a variety of environmental and physiological factors, such as daylength and body condition. To determine the consequences of this modulation for the organism, one also needs to investigate behavioral sensitivity to glucocorticoids. We examined the behavioral response of Gambel's white-crowned sparrows (Zonotrichia leucophrys gambelii) to elevated glucocorticoids. Using a behavioral assay in which a rapid and transient dose of corticosterone (CORT: the avian glucocorticoid) rapidly increases perch hopping, we first investigated the photoperiodic regulation of this behavioral response. Intermediate levels of CORT ( approximately 24 ng/ml), which increased activity in sparrows exposed to a long-day (breeding) photoperiod, had no behavioral effect in sparrows exposed to a short-day (winter) photoperiod. Hence, the neural mechanisms which regulate the behavioral response to CORT appear to be less sensitive under a winter photoperiod. Using the same behavioral assay, we also measured a dose-response curve for CORT's effects on activity in sparrows exposed to the long-day photoperiod. Intermediate levels (24 and 40 ng/ml) increased activity to threefold background levels, whereas high physiological levels (65 and 97 ng/ml) had no effect. Given that the behavioral response does not increase linearly with CORT, we can no longer assume that modulation of the adrenocortical response to stress will result in linear changes in behavior. |
| | |
Authors:
|
C W Breuner; J C Wingfield |
Related Documents
:
|
6473485 - Comparative studies with beta-(tyr9)melanotropin-(9-18) and amphetamine on open-field b... 15501295 - Analgesic and behavioral effects of amphetamine enantiomers, p-methoxyamphetamine and n... 12759125 - Dimenhydrinate produces a conditioned place preference in rats. 13954655 - Behavioral response rates in pigeons: effect of alpha-methyl-m-tyrosine. 19224145 - A method for improved verification of entire imrt plans by film dosimetry. 15996395 - Status epilepticus: clinical analysis of a treatment protocol based on midazolam and ph... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: Hormones and behavior Volume: 37 ISSN: 0018-506X ISO Abbreviation: Horm Behav Publication Date: 2000 Feb |
Date Detail:
|
Created Date: 2000-04-25 Completed Date: 2000-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0217764 Medline TA: Horm Behav Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 23-30 Citation Subset: IM |
Copyright Information:
|
Copyright 2000 Academic Press. |
Affiliation:
|
Department of Zoology, University of Washington, Seattle, Washington 98195, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Behavior, Animal / drug effects* Corticosterone / administration & dosage, blood, pharmacology* Dose-Response Relationship, Drug Photoperiod* Radioimmunoassay Songbirds / physiology* |
| Chemical | |
Reg. No./Substance:
|
50-22-6/Corticosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of thyroid hormone administration on estrogen-induced sex behavior in female mice.
Next Document: Corticosterone treatment has no effect on reproductive hormones or aggressive behavior in free-livin...