Document Detail

Rapid assessment of left ventricular segmental wall motion, ejection fraction, and volumes with single breath-hold, multi-slice TrueFISP MR imaging.
MedLine Citation:
PMID:  16755829     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: To reduce imaging time and complexity, we sought to determine whether single breath-hold, multi-slice TrueFISP (SB-MST) magnetic resonance imaging (MRI) method is comparable to standard multi-breath-hold, multi-slice TrueFISP (MB-MST) for assessment of left ventricular (LV) wall motion abnormality (WMA), volumes, and ejection fraction (EF). METHODS AND RESULTS: We studied 62 patients having cardiac MRI at 1.5-Tesla. After acquiring standard MB-MST (one slice per breath-hold), SB-MST was performed, acquiring 3 short- and 2 long-axis views over only 20 heartbeats. Using both techniques, wall motion was scored using a 6-point, 17-segment LV model for all scans (62 patients x 2 techniques/patient = 124 scans) on two separate occasions. Separately, EF and ventricular volumes were evaluated using both MB-MST and SB-MST. For all analyses, MB-MST was considered the standard against which SB-MST was compared. Twenty-six of 62 patients exhibited at least one segmental WMA by MB-MST. Exact agreement for wall motion was found in 965/1054 segments (92%, kappa = 0.74, p < 0.001), and agreement was within 1 score point in 1010/1054 segments (96%). Considering a score >1 abnormal, exact agreement for presence of WMA was found in 131/193 segments (68%) abnormal by MB-MST and for absence of WMA in 838/861 segments (97%) normal by MB-MST. Agreement within 1 score point occurred in 167/193 abnormal (87%) and in 843/861 normal segments (98%). There were no significant differences in agreement between first and second read of the data. Variability of SB-MST on read one versus read two was small (5%, 996/1054 segments read identically, p = ns) and statistically identical to variability of MB-MST on read one versus read two (4%, 1007/1054 segments read identically, p = ns). For end-diastolic volumes, end-systolic volumes, and EF using SB-MST compared to MB-MST, mean differences were 9 +/- 15 ml, 6 +/- 12 ml, and 2 +/- 5%, and correlations were r = 0.97, 0.98 and 0.95, respectively. CONCLUSION: SB-MST accurately assesses wall motion, volumes and EF. This approach may serve as a screening exam for assessment of WMA and, under select circumstances, may substitute for standard multi-breath-hold method in situations requiring rapid accurate assessments of LV function.
David S Fieno; Louise E J Thomson; Piotr J Slomka; Aiden Abidov; Hidetaka Nishina; Daisy Chien; Sean W Hayes; Rola Saouaf; Guido Germano; John D Friedman; Daniel S Berman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance     Volume:  8     ISSN:  1097-6647     ISO Abbreviation:  J Cardiovasc Magn Reson     Publication Date:  2006  
Date Detail:
Created Date:  2006-06-07     Completed Date:  2006-07-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815616     Medline TA:  J Cardiovasc Magn Reson     Country:  United States    
Other Details:
Languages:  eng     Pagination:  435-44     Citation Subset:  IM    
Department of Imaging (Division of Cardiology), and CSMC Burns and Allen Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
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MeSH Terms
Linear Models
Magnetic Resonance Imaging / methods*
Stroke Volume / physiology*
Ventricular Dysfunction, Left / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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