Document Detail


Rapid appearance of intraventricularly administered neuropeptides in the peripheral circulation.
MedLine Citation:
PMID:  6286044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
125I-Labeled cholecystokinin octapeptide ([125I]CCK-OP) diffuses rapidly by a non-carrier-mediated mechanism into the peripheral blood following injection into the lateral ventricle of a rabbit. In contrast, no [125I]CCK-OP was observed in the CSF following intravenous injection. This unidirectional free transport mechanism from CSF to blood may apply to other neuropeptides as well.
Authors:
E Passaro; H Debas; W Oldendorf; T Yamada
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  241     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-10-21     Completed Date:  1982-10-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  335-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / administration & dosage*
Cholecystokinin / administration & dosage*,  blood,  cerebrospinal fluid
Injections, Intraventricular
Iodine Radioisotopes
Kinetics
Peptide Fragments / administration & dosage*,  blood,  cerebrospinal fluid
Rabbits
Sincalide
Grant Support
ID/Acronym/Agency:
AM17328/AM/NIADDK NIH HHS; AM26268/AM/NIADDK NIH HHS
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Iodine Radioisotopes; 0/Peptide Fragments; 25126-32-3/Sincalide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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