| Rapid T1 mapping of mouse myocardium with saturation recovery Look-Locker method. | |
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MedLine Citation:
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PMID: 20632410 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dynamic contrast-enhanced MRI using gadolinium or manganese provides unique characterization of myocardium and its pathology. In this study, an electrocardiography (ECG) triggered saturation recovery Look-Locker method was developed and validated for fast cardiac T(1) mapping in small animal models. By sampling the initial portion of the longitudinal magnetization recovery curve, high temporal resolution (∼ 3 min) can be achieved at a high spatial resolution (195 × 390 μm2) in mouse heart without the aid of parallel imaging or echo-planar imaging. Validation studies were performed both in vitro on a phantom and in vivo on C57BL/6 mice (n = 6). Our results showed a strong agreement between T(1) measured by saturation recovery Look-Locker and by the standard saturation recovery method in vitro or inversion recovery Look-Locker in vivo. The utility of saturation recovery Look-Locker in dynamic contrast-enhanced MRI studies was demonstrated in manganese-enhanced MRI experiments in mice. Our results suggest that saturation recovery Look-Locker can provide rapid and accurate cardiac T(1) mapping for studies using small animal models. |
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Authors:
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Wen Li; Mark Griswold; Xin Yu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine Volume: 64 ISSN: 1522-2594 ISO Abbreviation: Magn Reson Med Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-28 Completed Date: 2011-03-08 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 8505245 Medline TA: Magn Reson Med Country: United States |
Other Details:
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Languages: eng Pagination: 1296-303 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Animals Cardiac-Gated Imaging Techniques / methods* Chlorides / diagnostic use* Contrast Media Heart / anatomy & histology* Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Magnetic Resonance Imaging, Cine / methods* Manganese Compounds / diagnostic use* Mice Mice, Inbred C57BL Reproducibility of Results Sensitivity and Specificity |
| Grant Support | |
ID/Acronym/Agency:
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HL73315/HL/NHLBI NIH HHS; HL86935/HL/NHLBI NIH HHS; R01 HL073315-01A1/HL/NHLBI NIH HHS; R01 HL073315-02/HL/NHLBI NIH HHS; R01 HL073315-03/HL/NHLBI NIH HHS; R01 HL073315-04/HL/NHLBI NIH HHS; R01 HL073315-05/HL/NHLBI NIH HHS; R01 HL073315-06A2/HL/NHLBI NIH HHS; R01 HL073315-07/HL/NHLBI NIH HHS; R01 HL086935-01/HL/NHLBI NIH HHS; R01 HL086935-02/HL/NHLBI NIH HHS; R01 HL086935-03/HL/NHLBI NIH HHS; R01 HL086935-03W1/HL/NHLBI NIH HHS; R01 HL086935-04/HL/NHLBI NIH HHS; U24 CA110943/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chlorides; 0/Contrast Media; 0/Manganese Compounds; 7773-01-5/manganese chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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