Document Detail

Rapid smoking may not be aversive in schizophrenia.
MedLine Citation:
PMID:  22318691     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Aversive smoking has been investigated as a smoking cessation technique that involves rapid smoking in a clinic or laboratory and typically involves (a) puffing every 6-10 s or (b) smoking 3 or more cigarettes sequentially in 8-20 min. Rapid smoking usually results in dizziness, sore throat, nausea, and other unpleasant feelings.
METHODS: To explore rapid smoking, 161 smokers (75 with schizophrenia [SS]; 86 controls [CON]) were assessed in a single day (24 ± 2 hr), ad libitum smoking topography session using the Clinical Research Support System micro portable topography device.
RESULTS: SS smoked significantly more cigarettes in the 24-hr period versus CON and the time between puffs, or interpuff interval (IPI) was shorter in SS versus CON by an average of 6.5 s (p < .001). The median IPI was also significantly shorter in SS versus CON (9.3 vs.15.7 s; p < .001). SS were twice as likely to have IPIs ≤ 6 s than CON (OR = 2.32, 95% CI = 1.68, 3.20; p < .001). SS were also more likely to smoke 3 or more cigarettes in any 20 min during a 24-hr topography session (OR = 2.32, 95% CI = 1.03, 2.44; p < .001). Rapid smoking was associated with baseline characteristics of smoking more cigarettes per day, higher Fagerström score, and higher carbon monoxide level but not with serum cotinine values or trans-3'-hydroxycotinine/cotinine ratios.
CONCLUSIONS: Using either definition, SS exhibit patterns of rapid smoking that they seemingly do not experience as aversive, since it reflects their naturalistic pattern of smoking, outside of the laboratory.
Jill M Williams; Kunal K Gandhi; Shou-En Lu; Marc L Steinberg; Neal L Benowitz
Publication Detail:
Type:  Controlled Clinical Trial; Journal Article; Research Support, N.I.H., Extramural     Date:  2012-02-07
Journal Detail:
Title:  Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco     Volume:  15     ISSN:  1469-994X     ISO Abbreviation:  Nicotine Tob. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-18     Completed Date:  2013-09-16     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  9815751     Medline TA:  Nicotine Tob Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  262-6     Citation Subset:  IM    
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MeSH Terms
Carbon Monoxide
Cotinine / analogs & derivatives,  blood
Middle Aged
Schizophrenic Psychology
Smoking Cessation / methods*,  psychology
Grant Support
Reg. No./Substance:
27323-64-4/hydroxycotinine; 7U1EE4V452/Carbon Monoxide; K5161X06LL/Cotinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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