Document Detail

Rapid HATU-Mediated Solution Phase siRNA Conjugation.
MedLine Citation:
PMID:  21744777     Owner:  NLM     Status:  Publisher    
Conditions for facile solution-phase amide conjugation of amine-modified siRNA with a diverse set of carboxylic acid partners using the coupling reagent HATU are described. These conditions eliminate the need for isolated activated esters and allow for rapid access to conjugates with a wide range of lipophilicity and functionality in good yield.
Jeffrey G Aaronson; Lee J Klein; Aaron A Momose; Ann M O'Brien; Anthony W Shaw; Thomas J Tucker; Yu Yuan; David M Tellers
Related Documents :
15173437 - Pharmacogenetics and individual variation in the range of amino acid adequacy: the biol...
19497577 - Aminoglycoside antibiotics may interfere with microbial amino sugar analysis.
6725467 - Identification of amino acid phenylthiohydantoins by multicomponent analysis of ultravi...
16545617 - Dimensionality of amino acid space and solvent accessibility prediction with neural net...
3460167 - Present experiences with omeprazole in the zollinger-ellison syndrome.
19653627 - Improving the stability and antioxidant properties of sesame oil: water-soluble spray-d...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-11
Journal Detail:
Title:  Bioconjugate chemistry     Volume:  -     ISSN:  1520-4812     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010319     Medline TA:  Bioconjug Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Medicinal Chemistry and ‡Department of Pharmaceutical Analytical Chemistry, Merck Research Laboratories, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Identifying static and kinetic lipid phenotypes by high resolution UPLC/MS: Unraveling diet-induced ...
Next Document:  A quantitative proteomic approach for cellulose degradation by Neurospora crassa.