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Rapid HATU-Mediated Solution Phase siRNA Conjugation.
MedLine Citation:
PMID:  21744777     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Conditions for facile solution-phase amide conjugation of amine-modified siRNA with a diverse set of carboxylic acid partners using the coupling reagent HATU are described. These conditions eliminate the need for isolated activated esters and allow for rapid access to conjugates with a wide range of lipophilicity and functionality in good yield.
Authors:
Jeffrey G Aaronson; Lee J Klein; Aaron A Momose; Ann M O'Brien; Anthony W Shaw; Thomas J Tucker; Yu Yuan; David M Tellers
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-11
Journal Detail:
Title:  Bioconjugate chemistry     Volume:  -     ISSN:  1520-4812     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9010319     Medline TA:  Bioconjug Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicinal Chemistry and ‡Department of Pharmaceutical Analytical Chemistry, Merck Research Laboratories, Merck & Co., Inc. , West Point, Pennsylvania 19486, United States.
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