Document Detail

Rapid cardiotonic effects of lipid emulsion infusion*.
MedLine Citation:
PMID:  23531591     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Bolus infusion of lipid emulsion can reverse cardiac pharmacotoxicity caused by local anesthetics and other lipophilic drugs. The mechanisms of this effect are not completely elucidated. The authors test the hypothesis that lipid emulsion infusion exerts direct, positive inotropic effects.
DESIGN: Prospective, randomized animal study.
SETTING: University research laboratory.
SUBJECTS: Adult male Sprague-Dawley rats.
INTERVENTIONS: Rats anesthetized with isoflurane were given intravenous infusions (9 mL/kg over 1 min) of either 20% soybean oil-based emulsion or saline.
MEASUREMENTS AND MAIN RESULTS: Arterial pressure and aortic flow were measured continuously in intact animals. Lipid infusion increased aortic flow and arterial pressure faster and to a greater degree than did the same volume of saline infusion. Isolated rat hearts were studied using an isovolumetric, constant flow, nonrecirculating system. Left ventricular pressure was monitored. The infusion of lipid emulsion in the isolated heart dose-dependently increased rate pressure product, dP/dt, -dP/dt, and myocardial oxygen demand.
CONCLUSIONS: Lipid emulsion exerts rapid, positive inotropic and positive lusitropic effects in both intact animal and isolated heart models. We hypothesize that this inotropy and the resulting increase in tissue blood flow contribute to the phenomenon of lipid reversal of cardiac toxicity caused by drug overdose.
Michael R Fettiplace; Richard Ripper; Kinga Lis; Bocheng Lin; Jason Lang; Brian Zider; Jing Wang; Israel Rubinstein; Guy Weinberg
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Critical care medicine     Volume:  41     ISSN:  1530-0293     ISO Abbreviation:  Crit. Care Med.     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-18     Completed Date:  2013-09-27     Revised Date:  2013-12-09    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e156-62     Citation Subset:  AIM; IM    
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MeSH Terms
Aorta, Abdominal / physiology*
Blood Flow Velocity / physiology
Blood Pressure / drug effects*,  physiology
Emulsions / pharmacology
Fat Emulsions, Intravenous / pharmacology*
Heart Rate / drug effects,  physiology
Models, Animal
Oxygen Consumption / drug effects,  physiology
Phospholipids / pharmacology*
Prospective Studies
Random Allocation
Rats, Sprague-Dawley
Regional Blood Flow / drug effects*,  physiology
Soybean Oil / pharmacology*
Vascular Resistance / drug effects,  physiology
Reg. No./Substance:
0/Emulsions; 0/Fat Emulsions, Intravenous; 0/Phospholipids; 0/soybean oil, phospholipid emulsion; 8001-22-7/Soybean Oil
Comment In:
Crit Care Med. 2013 Aug;41(8):2060-1   [PMID:  23863251 ]
Crit Care Med. 2013 Nov;41(11):e389   [PMID:  24162693 ]
Crit Care Med. 2013 Nov;41(11):e389-90   [PMID:  24162694 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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