Document Detail


Rapid 3D-imaging of phosphocreatine recovery kinetics in the human lower leg muscles with compressed sensing.
MedLine Citation:
PMID:  23023624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The rate of phosphocreatine (PCr) resynthesis following physical exercise is an accepted index of mitochondrial oxidative metabolism and has been studied extensively with unlocalized (31)P-MRS methods and small surface coils. Imaging experiments using volume coils that measure several muscles simultaneously can provide new insights into the variability of muscle function in healthy and diseased states. However, they are limited by long acquisition times relative to the dynamics of PCr recovery. This work focuses on the implementation of a compressed sensing technique to accelerate imaging of PCr resynthesis following physical exercise, using a modified three-dimensional turbo-spin-echo sequence and principal component analysis as sparsifying transform. The compressed sensing technique was initially validated using 2-fold retrospective undersampling of fully sampled data from four volunteers acquired on a 7T MRI system (voxel size: 1.6 mL, temporal resolution: 24 s), which led to an accurate estimation of the mono-exponential PCr resynthesis rate constant (mean error <6.4%). Acquisitions with prospective 2-fold acceleration (temporal resolution: 12 s) demonstrated that three-dimensional mapping of PCr resynthesis is possible at a temporal resolution that is sufficiently high for characterizing the recovery curve of several muscles in a single measurement.
Authors:
Prodromos Parasoglou; Li Feng; Ding Xia; Ricardo Otazo; Ravinder R Regatte
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-09-28
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  68     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-22     Completed Date:  2013-05-29     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1738-46     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Algorithms
Data Compression / methods*
Female
Humans
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods
Imaging, Three-Dimensional / methods*
Kinetics
Leg / physiology
Magnetic Resonance Imaging / methods*
Magnetic Resonance Spectroscopy / methods*
Male
Metabolic Clearance Rate
Muscle Contraction / physiology*
Muscle, Skeletal / metabolism*
Phosphocreatine / metabolism*
Phosphorus / analysis
Reproducibility of Results
Sensitivity and Specificity
Grant Support
ID/Acronym/Agency:
R01 AR053133/AR/NIAMS NIH HHS; R01 AR056260/AR/NIAMS NIH HHS; R01 AR060238/AR/NIAMS NIH HHS; R01-AR050260/AR/NIAMS NIH HHS; R01-AR053133/AR/NIAMS NIH HHS; R01-AR060238/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
020IUV4N33/Phosphocreatine; 27YLU75U4W/Phosphorus
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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